Seroatlas · Human Serome Atlas

HAPSTR1

HUWE1-associated protein modifying stress responses 1

Also known as: C16orf72, FLJ41272, HAPR1_HUMAN, PRO0149, TAPR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14CZ0
Gene: HAPSTR1
Ensembl: ENSG00000182831
Chromosome: 16
Canonical length: 275 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables ubiquitin protein ligase binding activity. Involved in negative regulation of signal transduction by p53 class mediator and regulation of cellular response to stress. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q14CZ0|HAPSTR1
     1  MEERKEEGEA EIQEHGPEHW FSKWERQCLA EAEQDEQLPP ELQEEAAAAA QPEHKQQKLW
    61  HLFQNSATAV AQLYKDRVCQ QPGLSLWVPF QNAATAVTNL YKESVDTHQR SFDIGIQIGY
   121  QRRNKDVLAW VKKRRRTIRR EDLISFLCGK VPPPRNSRAP PRLTVVSPNR ATSTETSSSV
   181  ETDLQPFREA IALHGLSGAM ASISVRSSTP GSPTHVSSGS NASRRRNGLH DVDLNTFISE
   241  EMALHLDNGG TRKRTSAQCG DVITDSPTHK RNRMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAPSTR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 100 nTPM
skeletal muscle: 30 nTPM
tongue: 26 nTPM
liver: 25 nTPM
blood vessel: 21 nTPM
parathyroid gland: 21 nTPM

Single-cell type

late spermatids: 1,081 nCPM
neutrophils: 370 nCPM
early spermatids: 258 nCPM
neutrophil progenitors: 102 nCPM
esophageal apical cells: 99 nCPM
monocytes: 94 nCPM

Immune cell

neutrophil: 11 nTPM
basophil: 5 nTPM
MAIT T-cell: 4.1 nTPM
gdT-cell: 3.6 nTPM
naive CD4 T-cell: 3.4 nTPM
non-classical monocyte: 3.3 nTPM

Brain region

cerebral cortex: 73 nTPM
basal ganglia: 67 nTPM
hippocampal formation: 67 nTPM
hypothalamus: 66 nTPM
thalamus: 66 nTPM
midbrain: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.98
DepMap mean gene effect: -0.38
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAPSTR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAPSTR1 as an antibody target. Whether an autoantibody or antibody against HAPSTR1 could matter depends on whether native HAPSTR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAPSTR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAPSTR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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