Seroatlas · Human Serome Atlas

ZNF777

Zinc finger protein 777

Also known as: KIAA1285, ZN777_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULD5
Gene: ZNF777
Ensembl: ENSG00000196453
Chromosome: 7
Canonical length: 831 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of cell population proliferation; and protein heterooligomerization. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

831 residues, UniProt reviewed canonical sequence.

>Q9ULD5|ZNF777
     1  MENQRSSPLS FPSVPQEETL RQAPAGLPRE TLFQSRVLPP KEIPSLSPTI PRQGSLPQTS
    61  SAPKQETSGR MPHVLQKGPS LLCSAASEQE TSLQGPLASQ EGTQYPPPAA AEQEVSLLSH
   121  SPHHQEAPVH SPEAPEKDPL TLSPTVPETD MDPLLQSPVS QKDTPFQISS AVQKEQPLPT
   181  AEITRLAVWA AVQAVERKLE AQAMRLLTLE GRTGTNEKKI ADCEKTAVEF ANHLESKWVV
   241  LGTLLQEYGL LQRRLENMEN LLKNRNFWIL RLPPGSNGEV PKVPVTFDDV AVHFSEQEWG
   301  NLSEWQKELY KNVMRGNYES LVSMDYAISK PDLMSQMERG ERPTMQEQED SEEGETPTDP
   361  SAAHDGIVIK IEVQTNDEGS ESLETPEPLM GQVEEHGFQD SELGDPCGEQ PDLDMQEPEN
   421  TLEESTEGSS EFSELKQMLV QQRNCTEGIV IKTEEQDEEE EEEEEDELPQ HLQSLGQLSG
   481  RYEASMYQTP LPGEMSPEGE ESPPPLQLGN PAVKRLAPSV HGERHLSENR GASSQQQRNR
   541  RGERPFTCME CGKSFRLKIN LIIHQRNHIK EGPYECAECE ISFRHKQQLT LHQRIHRVRG
   601  GCVSPERGPT FNPKHALKPR PKSPSSGSGG GGPKPYKCPE CDSSFSHKSS LTKHQITHTG
   661  ERPYTCPECK KSFRLHISLV IHQRVHAGKH EVSFICSLCG KSFSRPSHLL RHQRTHTGER
   721  PFKCPECEKS FSEKSKLTNH CRVHSRERPH ACPECGKSFI RKHHLLEHRR IHTGERPYHC
   781  AECGKRFTQK HHLLEHQRAH TGERPYPCTH CAKCFRYKQS LKYHLRTHTG E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF777 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 13 nTPM
skin: 11 nTPM
cerebral cortex: 10 nTPM
endometrium: 10 nTPM
cerebellum: 9.9 nTPM
ovary: 9.7 nTPM

Single-cell type

gonadotrophs: 17 nCPM
thyrotrophs: 17 nCPM
myonuclei: 16 nCPM
rod photoreceptor cells: 15 nCPM
lactotrophs: 15 nCPM
corticotrophs: 14 nCPM

Immune cell

naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 17 nTPM
hypothalamus: 16 nTPM
hippocampal formation: 16 nTPM
amygdala: 16 nTPM
medulla oblongata: 16 nTPM
cerebellum: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 3.09
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF777 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FAM9B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF777 as an antibody target. Whether an autoantibody or antibody against ZNF777 could matter depends on whether native ZNF777 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF777 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF777 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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