Seroatlas · Human Serome Atlas

FAM98B

Protein FAM98B

Also known as: FA98B_HUMAN, FLJ38426

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q52LJ0
Gene
FAM98B
Ensembl
ENSG00000171262
Chromosome
15
Canonical length
433 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables identical protein binding activity and protein methyltransferase activity. Involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Located in cytoplasm and nucleoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q52LJ0|FAM98B
     1  MRGPEPGPQP TMEGDVLDTL EALGYKGPLL EEQALTKAAE GGLSSPEFSE LCIWLGSQIK
    61  SLCNLEESIT SAGRDDLESF QLEISGFLKE MACPYSVLIS GDIKDRLKKK EDCLKLLLFL
   121  STELQASQIL QNKKHKNSQL DKNSEVYQEV QAMFDTLGIP KSTTSDIPHM LNQVESKVKD
   181  ILSKVQKNHV GKPLLKMDLN SEQAEQLERI NDALSCEYEC RRRMLMKRLD VTVQSFGWSD
   241  RAKVKTDDIA RIYQPKRYAL SPKTTITMAH LLAAREDLSK IIRTSSGTSR EKTACAINKV
   301  LMGRVPDRGG RPNEIEPPPP EMPPWQKRQE GGGGRGGWGG GGGGGGRGGG GGGGGRGGWG
   361  GGGGGWGGGG GGGGGWGGGG GGGRGGFQGR GDYGGRGGYG GRGGYGGRGY GDPYGGGGGG
   421  GGGGGGGGGY RRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM98B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 27 nTPM
  • retina: 18 nTPM
  • parathyroid gland: 18 nTPM
  • cerebral cortex: 16 nTPM
  • tongue: 15 nTPM
  • colon: 14 nTPM

Single-cell type

  • erythrocyte progenitors: 92 nCPM
  • megakaryocyte progenitors: 69 nCPM
  • megakaryocyte-erythroid progenitors: 62 nCPM
  • corticotrophs: 46 nCPM
  • neutrophil progenitors: 45 nCPM
  • hematopoietic stem cells: 42 nCPM

Immune cell

  • naive CD4 T-cell: 3.4 nTPM
  • gdT-cell: 2.8 nTPM
  • memory CD4 T-cell: 2.8 nTPM
  • naive CD8 T-cell: 2.6 nTPM
  • MAIT T-cell: 2.4 nTPM
  • basophil: 2.3 nTPM

Brain region

  • cerebellum: 30 nTPM
  • white matter: 21 nTPM
  • hypothalamus: 19 nTPM
  • cerebral cortex: 18 nTPM
  • basal ganglia: 17 nTPM
  • spinal cord: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.01
gnomAD missense Z
0.44
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM98B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM98B as an antibody target. Whether an autoantibody or antibody against FAM98B could matter depends on whether native FAM98B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM98B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM98B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM98B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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