Seroatlas · Human Serome Atlas

FAM98A

Protein FAM98A

Also known as: DKFZP564F0522, FA98A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCA5
Gene: FAM98A
Ensembl: ENSG00000119812
Chromosome: 2
Canonical length: 518 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables protein methyltransferase activity. Involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q8NCA5|FAM98A
     1  MECDLMETDI LESLEDLGYK GPLLEDGALS QAVSAGASSP EFTKLCAWLV SELRVLCKLE
    61  ENVQATNSPS EAEEFQLEVS GLLGEMNCPY LSLTSGDVTK RLLIQKNCLL LLTYLISELE
   121  AARMLCVNAP PKKAQEGGGS EVFQELKGIC IALGMSKPPA NITMFQFFSG IEKKLKETLA
   181  KVPPNHVGKP LLKKPMGPAH WEKIEAINQA IANEYEVRRK LLIKRLDVTV QSFGWSDRAK
   241  SQTEKLAKVY QPKRSVLSPK TTISVAHLLA ARQDLSKILR TSSGSIREKT ACAINKVLMG
   301  RVPDRGGRPN EIEPPPPEMP PWQKRQDGPQ QQTGGRGGGR GGYEHSSYGG RGGHEQGGGR
   361  GGRGGYDHGG RGGGRGNKHQ GGWTDGGSGG GGGYQDGGYR DSGFQPGGYH GGHSSGGYQG
   421  GGYGGFQTSS SYTGSGYQGG GYQQDNRYQD GGHHGDRGGG RGGRGGRGGR GGRAGQGGGW
   481  GGRGSQNYHQ GGQFEQHFQH GGYQYNHSGF GQGRHYTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM98A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

testis: 47 nTPM
skeletal muscle: 46 nTPM
parathyroid gland: 45 nTPM
tongue: 38 nTPM
heart muscle: 38 nTPM
smooth muscle: 34 nTPM

Single-cell type

cardiomyocytes: 346 nCPM
myonuclei: 109 nCPM
sertoli cells: 91 nCPM
plasma cells: 85 nCPM
megakaryocyte progenitors: 74 nCPM
late primary spermatocytes: 72 nCPM

Immune cell

memory B-cell: 7.3 nTPM
T-reg: 6.8 nTPM
naive CD4 T-cell: 6.2 nTPM
MAIT T-cell: 5.5 nTPM
intermediate monocyte: 5.4 nTPM
gdT-cell: 4.8 nTPM

Brain region

white matter: 35 nTPM
hippocampal formation: 30 nTPM
cerebral cortex: 28 nTPM
cerebellum: 27 nTPM
basal ganglia: 25 nTPM
thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.55
gnomAD missense Z: -0.06
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of FAM98A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM98A as an antibody target. Whether an autoantibody or antibody against FAM98A could matter depends on whether native FAM98A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM98A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM98A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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