Seroatlas · Human Serome Atlas

MT1X

Metallothionein-1X

Also known as: MT-1l, MT1, MT1X_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P80297
Gene: MT1X
Ensembl: ENSG00000187193
Chromosome: 16
Canonical length: 61 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable copper ion binding activity and zinc ion binding activity. Involved in cellular response to cadmium ion; cellular response to erythropoietin; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

61 residues, UniProt reviewed canonical sequence.

>P80297|MT1X
     1  MDPNCSCSPV GSCACAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC KGTSDKCSCC
    61  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT1X can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 7,048 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 7,048 nTPM
liver: 4,654 nTPM
skin: 2,042 nTPM
tongue: 2,001 nTPM
blood vessel: 1,990 nTPM
pancreas: 1,856 nTPM

Single-cell type

gastric chief cells: 7,303 nCPM
hepatocytes: 5,210 nCPM
parietal cells: 3,211 nCPM
thymic myoid cells: 3,033 nCPM
enterocytes: 2,166 nCPM
epididymal efferent duct absorptive cells: 1,749 nCPM

Immune cell

naive CD8 T-cell: 99 nTPM
memory CD8 T-cell: 95 nTPM
T-reg: 90 nTPM
MAIT T-cell: 86 nTPM
memory CD4 T-cell: 84 nTPM
naive CD4 T-cell: 79 nTPM

Brain region

thalamus: 541 nTPM
basal ganglia: 520 nTPM
midbrain: 460 nTPM
cerebellum: 442 nTPM
pons: 422 nTPM
medulla oblongata: 411 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MT1X in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FAM168A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT1X as an antibody target. Whether an autoantibody or antibody against MT1X could matter depends on whether native MT1X is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT1X is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT1X as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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