Seroatlas · Human Serome Atlas

ETAA1

Ewing's tumor-associated antigen 1

Also known as: ETAA1_HUMAN, ETAA16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NY74
Gene
ETAA1
Ensembl
ENSG00000143971
Chromosome
2
Canonical length
926 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables protein serine/threonine kinase activator activity. Involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of cell cycle phase transition; and replication fork processing. Located in cytosol; nuclear lumen; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

926 residues, UniProt reviewed canonical sequence.

>Q9NY74|ETAA1
     1  MSRRRKHDDS PSPKKTPHKT VAAEECGSVV EPGRRRLRSA RGSWPCGARE GPPGPVRQRE
    61  QPPTAALCSK SNPEERYETP KRALKMDSLS SSFSSPNDPD GQNDIFWDQN SPLTKQLGKG
   121  RKKQIYTTDS DEISHIVNRI APQDEKPTTN SMLDMWIGET AIPCTPSVAK GKSRAKISCT
   181  KLKTQSQEEE LMKLAKQFDK NMEELDVIQE QNKRNYDFTQ MISETEILSN YKDNIQMWSL
   241  HNIVPEIDNA TKKPIKGNTK ISVANNQNSS QKPFDQIAEA AFNAIFDGST QKCSGQLSQE
   301  LPEAFWSTSN TTFVKTNALK EEKIITNETL VIEKLSNKTP RSLSSQVDTP IMTKSCVTSC
   361  TKEPETSNKY IDAFTTSDFE DDWENLLGSE PFAMQNIDMP ELFPSKTAHV TDQKEICTFN
   421  SKTVKNTSRA NTSPDARLGD SKVLQDLSSK TYDRELIDAE YRFSPNSNKS NKLSTGNKMK
   481  FENSSNKIVI QDEIQNCIVT SNLTKIKEDI LTNSTEASER KSALNTRYSN EQKNKCILNQ
   541  SIKAPVNTDL FGSANLGSKT SVSNPNQTSA SKVGSFFDDW NDPSFANEII KACHQLDNTW
   601  EADDVDDDLL YQACDDIERL TQQQDIRKDS KTSESICEIN NNSEHGAKLT QQQDIRKDSK
   661  TSESICEINN NSEHGAKNMF AISKQGSNLV QSKHLNPGSI SVQTSLTNSS QIDKPMKMEK
   721  GEMYGNSPRF LGATNLTMYS KISNCQINNL HVSYTNTDVP IQVNSSKLVL PGSSSLNVTS
   781  DHMNTEITTY KKKLSTNQPC HKTVTDEAQS NLNTTVGFSK FTFTRMKNSQ ILSQFNQNCI
   841  TGSMSDTKIT QGVEKKKGVN PLLEEAVGQQ SLVKLSESLK QSSKEEEEKN RKCSPEEIQR
   901  KRQEALVRRM AKARASSVNA APTSFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETAA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
7.2 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 7.2 nTPM
  • breast: 6.7 nTPM
  • ovary: 6.5 nTPM
  • lymph node: 6.1 nTPM
  • epididymis: 5.9 nTPM
  • thymus: 5.9 nTPM

Single-cell type

  • adrenal cortex cells: 50 nCPM
  • medullary thymic epithelial cells: 34 nCPM
  • sertoli cells: 28 nCPM
  • cardiomyocytes: 27 nCPM
  • myonuclei: 25 nCPM
  • leydig cells: 24 nCPM

Immune cell

  • naive B-cell: 3.6 nTPM
  • memory B-cell: 3.5 nTPM
  • T-reg: 3.2 nTPM
  • naive CD4 T-cell: 2.7 nTPM
  • non-classical monocyte: 2.7 nTPM
  • MAIT T-cell: 2.4 nTPM

Brain region

  • cerebellum: 6.6 nTPM
  • choroid plexus: 6.4 nTPM
  • white matter: 5.4 nTPM
  • basal ganglia: 4.5 nTPM
  • medulla oblongata: 4.4 nTPM
  • pons: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.01
gnomAD missense Z
0.24
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ewing's tumour-associated antigen 1
  • Ewing's tumour-associated antigen 1 homologue

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ETAA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ETAA1 as an antibody target. Whether an autoantibody or antibody against ETAA1 could matter depends on whether native ETAA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ETAA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ETAA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ETAA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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