Seroatlas · Human Serome Atlas

ELP5

Elongator complex protein 5

Also known as: C17orf81, DERP6, ELP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TE02
Gene: ELP5
Ensembl: ENSG00000170291
Chromosome: 17
Canonical length: 300 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Located in cytosol and nucleoplasm. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q8TE02|ELP5
     1  MLDSLLALGG LVLLRDSVEW EGRSLLKALV KKSALCGEQV HILGCEVSEE EFREGFDSDI
    61  NNRLVYHDFF RDPLNWSKTE EAFPGGPLGA LRAMCKRTDP VPVTIALDSL SWLLLRLPCT
   121  TLCQVLHAVS HQDSCPGDSS SVGKVSVLGL LHEELHGPGP VGALSSLAQT EVTLGGTMGQ
   181  ASAHILCRRP RQRPTDQTQW FSILPDFSLD LQEGPSVESQ PYSDPHIPPV DPTTHLTFNL
   241  HLSKKEREAR DSLILPFQFS SEKQQALLRP RPGQATSHIF YEPDAYDDLD QEDPDDDLDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 161 nTPM

Expression across tissuesHPA

Tissue

testis: 161 nTPM
tongue: 79 nTPM
heart muscle: 56 nTPM
skeletal muscle: 55 nTPM
liver: 53 nTPM
adrenal gland: 44 nTPM

Single-cell type

late spermatids: 743 nCPM
late primary spermatocytes: 285 nCPM
early spermatids: 189 nCPM
parietal cells: 41 nCPM
early primary spermatocytes: 28 nCPM
tuft cells: 23 nCPM

Immune cell

plasmacytoid DC: 36 nTPM
T-reg: 35 nTPM
myeloid DC: 33 nTPM
MAIT T-cell: 30 nTPM
intermediate monocyte: 30 nTPM
naive CD8 T-cell: 29 nTPM

Brain region

thalamus: 28 nTPM
white matter: 28 nTPM
cerebellum: 27 nTPM
basal ganglia: 26 nTPM
medulla oblongata: 26 nTPM
midbrain: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.91
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Elongator complex protein 5
Elongator subunit Iki1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELP5 as an antibody target. Whether an autoantibody or antibody against ELP5 could matter depends on whether native ELP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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