Seroatlas · Human Serome Atlas

SIRT7

NAD-dependent protein deacetylase sirtuin-7

Also known as: SIR7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRC8
Gene
SIRT7
Ensembl
ENSG00000187531
Chromosome
17
Canonical length
400 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q9NRC8|SIRT7
     1  MAAGGLSRSE RKAAERVRRL REEQQRERLR QVSRILRKAA AERSAEEGRL LAESADLVTE
    61  LQGRSRRREG LKRRQEEVCD DPEELRGKVR ELASAVRNAK YLVVYTGAGI STAASIPDYR
   121  GPNGVWTLLQ KGRSVSAADL SEAEPTLTHM SITRLHEQKL VQHVVSQNCD GLHLRSGLPR
   181  TAISELHGNM YIEVCTSCVP NREYVRVFDV TERTALHRHQ TGRTCHKCGT QLRDTIVHFG
   241  ERGTLGQPLN WEAATEAASR ADTILCLGSS LKVLKKYPRL WCMTKPPSRR PKLYIVNLQW
   301  TPKDDWAALK LHGKCDDVMR LLMAELGLEI PAYSRWQDPI FSLATPLRAG EEGSHSRKSL
   361  CRSREEAPPG DRGAPLSSAP ILGGWFGRGC TKRTKRKKVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIRT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 42 nTPM
  • skin: 22 nTPM
  • bone marrow: 22 nTPM
  • spleen: 19 nTPM
  • vagina: 18 nTPM
  • stomach: 17 nTPM

Single-cell type

  • esophageal apical cells: 497 nCPM
  • esophageal suprabasal cells: 177 nCPM
  • foveolar cells: 122 nCPM
  • colonocytes: 84 nCPM
  • suprabasal keratinocytes: 80 nCPM
  • neutrophils: 79 nCPM

Immune cell

  • eosinophil: 22 nTPM
  • naive B-cell: 7 nTPM
  • basophil: 4.6 nTPM
  • memory B-cell: 4.6 nTPM
  • neutrophil: 4.5 nTPM
  • intermediate monocyte: 3.9 nTPM

Brain region

  • thalamus: 3.4 nTPM
  • medulla oblongata: 3 nTPM
  • white matter: 2.9 nTPM
  • cerebellum: 2.8 nTPM
  • choroid plexus: 2.8 nTPM
  • pons: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.89
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIRT7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIRT7 as an antibody target. Whether an autoantibody or antibody against SIRT7 could matter depends on whether native SIRT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIRT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIRT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIRT7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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