Seroatlas · Human Serome Atlas

EIF1AD

Probable RNA-binding protein EIF1AD

Also known as: EIF1A_HUMAN, haponin, MGC11102

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9N8
Gene: EIF1AD
Ensembl: ENSG00000175376
Chromosome: 11
Canonical length: 165 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>Q8N9N8|EIF1AD
     1  MSQATKRKHV VKEVLGEHIV PSDQQQIVRV LRTPGNNLHE VETAQGQRFL VSMPSKYRKN
    61  IWIKRGDFLI VDPIEEGEKV KAEISFVLCK DHVRSLQKEG FWPEAFSEVA EKHNNRNRQT
   121  QPELPAEPQL SGEESSSEDD SDLFVNTNRR QYHESEEESE EEEAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF1AD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 42 nTPM
tonsil: 26 nTPM
skeletal muscle: 25 nTPM
lymph node: 22 nTPM
tongue: 22 nTPM
skin: 21 nTPM

Single-cell type

esophageal apical cells: 51 nCPM
megakaryocytes: 50 nCPM
granulosa cells: 37 nCPM
suprabasal keratinocytes: 37 nCPM
late primary spermatocytes: 36 nCPM
syncytiotrophoblasts: 33 nCPM

Immune cell

basophil: 53 nTPM
myeloid DC: 21 nTPM
non-classical monocyte: 21 nTPM
classical monocyte: 21 nTPM
memory B-cell: 18 nTPM
naive B-cell: 18 nTPM

Brain region

cerebral cortex: 31 nTPM
cerebellum: 31 nTPM
hypothalamus: 29 nTPM
white matter: 29 nTPM
thalamus: 26 nTPM
pons: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -1.35
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Translation initiation factor 1A (eIF-1A)
RNA-binding domain, S1, IF1 type
Nucleic acid-binding, OB-fold
Translation initiation factor 1A / IF-1
Probable RNA-binding protein EIF1AD

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF1AD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF1AD as an antibody target. Whether an autoantibody or antibody against EIF1AD could matter depends on whether native EIF1AD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF1AD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF1AD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...