Seroatlas · Human Serome Atlas

EEPD1

Endonuclease/exonuclease/phosphatase family domain-containing protein 1

Also known as: EEPD1_HUMAN, KIAA1706

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L9B9
Gene
EEPD1
Ensembl
ENSG00000122547
Chromosome
7
Canonical length
569 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Vesicles

OverviewNCBI Gene

Predicted to enable DNA binding activity and catalytic activity. Involved in positive regulation of cholesterol efflux. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q7L9B9|EEPD1
     1  MGSTLGCHRS IPRDPSDLSH SRKFSAACNF SNILVNQERL NINTATEEEL MTLPGVTRAV
    61  ARSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV SSKGSSAQHS PSSLRRDLLA
   121  EQQPHHLATA VPLTPRVNIN TATPAQLMSV RGLSEKMALS IVDFRREHGP FRSVEDLVRM
   181  DGINAAFLDR IRHQVFAERS RPPSTHTNGG LTFTAKPHPS PTSLSLQSED LDLPPGGPTQ
   241  IISTRPSVEA FGGTRDGRPV LRLATWNLQG CSVEKANNPG VREVVCMTLL ENSIKLLAVQ
   301  ELLDREALEK FCTELNQPTL PNIRKWKGPR GCWKAVVAEK PSSQLQKGAG YAGFLWDAAA
   361  GMELRDAGSQ ESSPSNGHGK LAGPSPYLGR FKVGSHDLTL VNLHLAALTL LGSENPSKNH
   421  SDGHRLASFA QTLQETLKGE KDVIILGDFG QGPDSNDYDI LRKEKFHHLI PAHTFTNIST
   481  KNPQGSKSLD NIWISKSLKK VFTGHWAVVR EGLTNPWIPD NWSWGGVASE HCPVLAEFYT
   541  EKDWSKKDAP RNGSGVALER SEANIKHER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EEPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 45 nTPM
  • liver: 24 nTPM
  • adipose tissue: 19 nTPM
  • breast: 18 nTPM
  • stomach: 16 nTPM
  • spinal cord: 15 nTPM

Single-cell type

  • adipocytes: 644 nCPM
  • neutrophils: 332 nCPM
  • cholangiocytes: 332 nCPM
  • myonuclei: 319 nCPM
  • foveolar cells: 274 nCPM
  • cone photoreceptor cells: 257 nCPM

Immune cell

  • eosinophil: 52 nTPM
  • neutrophil: 47 nTPM
  • basophil: 23 nTPM
  • memory CD4 T-cell: 23 nTPM
  • T-reg: 12 nTPM
  • memory CD8 T-cell: 6.6 nTPM

Brain region

  • white matter: 28 nTPM
  • thalamus: 17 nTPM
  • midbrain: 16 nTPM
  • pons: 16 nTPM
  • cerebral cortex: 15 nTPM
  • basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.05
gnomAD missense Z
1.33
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EEPD1 as an antibody target. Whether an autoantibody or antibody against EEPD1 could matter depends on whether native EEPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EEPD1 is annotated at the cell surface, where native EEPD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EEPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EEPD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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