Seroatlas · Human Serome Atlas

DNAJC10

DnaJ homolog subfamily C member 10

Also known as: DJC10_HUMAN, ERdj5, PDIA19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXB1
Gene: DNAJC10
Ensembl: ENSG00000077232
Chromosome: 2
Canonical length: 793 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

793 residues, UniProt reviewed canonical sequence.

>Q8IXB1|DNAJC10
     1  MGVWLNKDDY IRDLKRIILC FLIVYMAILV GTDQDFYSLL GVSKTASSRE IRQAFKKLAL
    61  KLHPDKNPNN PNAHGDFLKI NRAYEVLKDE DLRKKYDKYG EKGLEDNQGG QYESWNYYRY
   121  DFGIYDDDPE IITLERREFD AAVNSGELWF VNFYSPGCSH CHDLAPTWRD FAKEVDGLLR
   181  IGAVNCGDDR MLCRMKGVNS YPSLFIFRSG MAPVKYHGDR SKESLVSFAM QHVRSTVTEL
   241  WTGNFVNSIQ TAFAAGIGWL ITFCSKGGDC LTSQTRLRLS GMLDGLVNVG WMDCATQDNL
   301  CKSLDITTST TAYFPPGATL NNKEKNSILF LNSLDAKEIY LEVIHNLPDF ELLSANTLED
   361  RLAHHRWLLF FHFGKNENSN DPELKKLKTL LKNDHIQVGR FDCSSAPDIC SNLYVFQPSL
   421  AVFKGQGTKE YEIHHGKKIL YDILAFAKES VNSHVTTLGP QNFPANDKEP WLVDFFAPWC
   481  PPCRALLPEL RRASNLLYGQ LKFGTLDCTV HEGLCNMYNI QAYPTTVVFN QSNIHEYEGH
   541  HSAEQILEFI EDLMNPSVVS LTPTTFNELV TQRKHNEVWM VDFYSPWCHP CQVLMPEWKR
   601  MARTLTGLIN VGSIDCQQYH SFCAQENVQR YPEIRFFPPK SNKAYHYHSY NGWNRDAYSL
   661  RIWGLGFLPQ VSTDLTPQTF SEKVLQGKNH WVIDFYAPWC GPCQNFAPEF ELLARMIKGK
   721  VKAGKVDCQA YAQTCQKAGI RAYPTVKFYF YERAKRNFQE EQINTRDAKA IAALISEKLE
   781  TLRNQGKRNK DEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 108 nTPM

Expression across tissuesHPA

Tissue

epididymis: 108 nTPM
endometrium: 38 nTPM
tonsil: 38 nTPM
testis: 36 nTPM
thyroid gland: 35 nTPM
stomach: 33 nTPM

Single-cell type

epididymal principal cells: 434 nCPM
late primary spermatocytes: 209 nCPM
early spermatids: 206 nCPM
gonadotrophs: 172 nCPM
goblet cells: 165 nCPM
corticotrophs: 134 nCPM

Immune cell

memory B-cell: 23 nTPM
naive B-cell: 17 nTPM
myeloid DC: 16 nTPM
classical monocyte: 12 nTPM
intermediate monocyte: 11 nTPM
non-classical monocyte: 9.9 nTPM

Brain region

hypothalamus: 27 nTPM
white matter: 26 nTPM
medulla oblongata: 23 nTPM
choroid plexus: 22 nTPM
midbrain: 22 nTPM
spinal cord: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

DnaJ domain
Thioredoxin domain
Thioredoxin, conserved site
Thioredoxin-like superfamily
Chaperone J-domain superfamily
Thioredoxin
DnaJ domain
DnaJ homologue subfamily C member 10
ERdj5, first thioredoxin domain
ERdj5, C-terminal thioredoxin domain
Endoplasmic reticulum disulfide reductase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC10 as an antibody target. Whether an autoantibody or antibody against DNAJC10 could matter depends on whether native DNAJC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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