Seroatlas · Human Serome Atlas

DTD1

D-aminoacyl-tRNA deacylase 1

Also known as: bA379J5.3, bA555E18.1, C20orf88, DTD1_HUMAN, DUEB, HARS2, MGC119131, MGC41905, pqn-68

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEA8
Gene: DTD1
Ensembl: ENSG00000125821
Chromosome: 20
Canonical length: 209 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q8TEA8|DTD1
     1  MKAVVQRVTR ASVTVGGEQI SAIGRGICVL LGISLEDTQK ELEHMVRKIL NLRVFEDESG
    61  KHWSKSVMDK QYEILCVSQF TLQCVLKGNK PDFHLAMPTE QAEGFYNSFL EQLRKTYRPE
   121  LIKDGKFGAY MQVHIQNDGP VTIELESPAP GTATSDPKQL SKLEKQQQRK EKTRAKGPSE
   181  SSKERNTPRK EDRSASSGAE GDVSSEREP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 8.7 nTPM
spinal cord: 8.2 nTPM
thyroid gland: 7.9 nTPM
hypothalamus: 7.5 nTPM
parathyroid gland: 7.3 nTPM
kidney: 6.8 nTPM

Single-cell type

megakaryocytes: 272 nCPM
differentiating spermatogonia: 139 nCPM
early primary spermatocytes: 128 nCPM
megakaryocyte progenitors: 112 nCPM
esophageal apical cells: 103 nCPM
esophageal suprabasal cells: 102 nCPM

Immune cell

gdT-cell: 1.8 nTPM
basophil: 1.7 nTPM
myeloid DC: 1.5 nTPM
NK-cell: 1.4 nTPM
memory B-cell: 1.1 nTPM
intermediate monocyte: 1 nTPM

Brain region

hypothalamus: 6.5 nTPM
pons: 6.2 nTPM
thalamus: 5.9 nTPM
white matter: 5.9 nTPM
medulla oblongata: 5.8 nTPM
spinal cord: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DTD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DTD1 as an antibody target. Whether an autoantibody or antibody against DTD1 could matter depends on whether native DTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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