Seroatlas · Human Serome Atlas

DNASE1L2

Deoxyribonuclease-1-like 2

Also known as: DNAS1L2, DNSL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92874
Gene: DNASE1L2
Ensembl: ENSG00000167968
Chromosome: 16
Canonical length: 299 aa
Protein class: Predicted secreted proteins
Subcellular location: Mitochondria
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to act upstream of or within corneocyte development and hair follicle development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q92874|DNASE1L2
     1  MGGPRALLAA LWALEAAGTA ALRIGAFNIQ SFGDSKVSDP ACGSIIAKIL AGYDLALVQE
    61  VRDPDLSAVS ALMEQINSVS EHEYSFVSSQ PLGRDQYKEM YLFVYRKDAV SVVDTYLYPD
   121  PEDVFSREPF VVKFSAPGTG ERAPPLPSRR ALTPPPLPAA AQNLVLIPLH AAPHQAVAEI
   181  DALYDVYLDV IDKWGTDDML FLGDFNADCS YVRAQDWAAI RLRSSEVFKW LIPDSADTTV
   241  GNSDCAYDRI VACGARLRRS LKPQSATVHD FQEEFGLDQT QALAISDHFP VEVTLKFHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNASE1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

skin: 44 nTPM
cerebellum: 16 nTPM
cerebral cortex: 6.5 nTPM
thyroid gland: 5.8 nTPM
pituitary gland: 4.7 nTPM
hypothalamus: 4.6 nTPM

Single-cell type

epididymal principal cells: 9 nCPM
thymic myoid cells: 4.1 nCPM
astrocytes: 3.7 nCPM
brain inhibitory neurons: 3.3 nCPM
brain excitatory neurons: 2.8 nCPM
other brain neurons: 2.8 nCPM

Immune cell

eosinophil: 0.2 nTPM
neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 14 nTPM
white matter: 14 nTPM
cerebral cortex: 13 nTPM
pons: 12 nTPM
medulla oblongata: 12 nTPM
basal ganglia: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNASE1L2 as an antibody target. Whether an autoantibody or antibody against DNASE1L2 could matter depends on whether native DNASE1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNASE1L2 is annotated as secreted, so native DNASE1L2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DNASE1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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