Seroatlas · Human Serome Atlas

DNAJC16

DnaJ homolog subfamily C member 16

Also known as: DJC16_HUMAN, KIAA0962

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2G8
Gene: DNAJC16
Ensembl: ENSG00000116138
Chromosome: 1
Canonical length: 782 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in regulation of autophagosome size. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

782 residues, UniProt reviewed canonical sequence.

>Q9Y2G8|DNAJC16
     1  MEVRKLSISW QFLIVLVLIL QILSALDFDP YRVLGVSRTA SQADIKKAYK KLAREWHPDK
    61  NKDPGAEDKF IQISKAYEIL SNEEKRSNYD QYGDAGENQG YQKQQQQREY RFRHFHENFY
   121  FDESFFHFPF NSERRDSIDE KYLLHFSHYV NEVVPDSFKK PYLIKITSDW CFSCIHIEPV
   181  WKEVIQELEE LGVGIGVVHA GYERRLAHHL GAHSTPSILG IINGKISFFH NAVVRENLRQ
   241  FVESLLPGNL VEKVTNKNYV RFLSGWQQEN KPHVLLFDQT PIVPLLYKLT AFAYKDYLSF
   301  GYVYVGLRGT EEMTRRYNIN IYAPTLLVFK EHINRPADVI QARGMKKQII DDFITRNKYL
   361  LAARLTSQKL FHELCPVKRS HRQRKYCVVL LTAETTKLSK PFEAFLSFAL ANTQDTVRFV
   421  HVYSNRQQEF ADTLLPDSEA FQGKSAVSIL ERRNTAGRVV YKTLEDPWIG SESDKFILLG
   481  YLDQLRKDPA LLSSEAVLPD LTDELAPVFL LRWFYSASDY ISDCWDSIFH NNWREMMPLL
   541  SLIFSALFIL FGTVIVQAFS DSNDERESSP PEKEEAQEKT GKTEPSFTKE NSSKIPKKGF
   601  VEVTELTDVT YTSNLVRLRP GHMNVVLILS NSTKTSLLQK FALEVYTFTG SSCLHFSFLS
   661  LDKHREWLEY LLEFAQDAAP IPNQYDKHFM ERDYTGYVLA LNGHKKYFCL FKPQKTVEEE
   721  EAIGSCSDVD SSLYLGESRG KPSCGLGSRP IKGKLSKLSL WMERLLEGSL QRFYIPSWPE
   781  LD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 11 nTPM
kidney: 11 nTPM
liver: 9.5 nTPM
parathyroid gland: 9.4 nTPM
retina: 8.3 nTPM
epididymis: 7.2 nTPM

Single-cell type

respiratory ciliated cells: 81 nCPM
myonuclei: 78 nCPM
lactotrophs: 71 nCPM
proximal tubule cells: 69 nCPM
prostatic hillock cells: 66 nCPM
thyrotrophs: 63 nCPM

Immune cell

MAIT T-cell: 3.9 nTPM
naive CD4 T-cell: 3.5 nTPM
memory B-cell: 3.4 nTPM
naive B-cell: 3.1 nTPM
naive CD8 T-cell: 3 nTPM
memory CD4 T-cell: 2.8 nTPM

Brain region

choroid plexus: 27 nTPM
cerebral cortex: 23 nTPM
white matter: 23 nTPM
cerebellum: 22 nTPM
basal ganglia: 22 nTPM
hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of autophagosome size

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

DnaJ domain
Thioredoxin domain
DnaJ domain, conserved site
Thioredoxin-like superfamily
Chaperone J-domain superfamily
Thioredoxin
DnaJ domain
DnaJ homolog subfamily C member 16, TRX domain
DnaJ Homolog Subfamily C Member 16

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC16 as an antibody target. Whether an autoantibody or antibody against DNAJC16 could matter depends on whether native DNAJC16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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