Seroatlas · Human Serome Atlas

DIMT1

Dimethyladenosine transferase

Also known as: DIM1_HUMAN, DIMT1L, HSA9761

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNQ2
Gene
DIMT1
Ensembl
ENSG00000086189
Chromosome
5
Canonical length
313 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q9UNQ2|DIMT1
     1  MPKVKSGAIG RRRGRQEQRR ELKSAGGLMF NTGIGQHILK NPLIINSIID KAALRPTDVV
    61  LEVGPGTGNM TVKLLEKAKK VVACELDPRL VAELHKRVQG TPVASKLQVL VGDVLKTDLP
   121  FFDTCVANLP YQISSPFVFK LLLHRPFFRC AILMFQREFA LRLVAKPGDK LYCRLSINTQ
   181  LLARVDHLMK VGKNNFRPPP KVESSVVRIE PKNPPPPINF QEWDGLVRIT FVRKNKTLSA
   241  AFKSSAVQQL LEKNYRIHCS VHNIIIPEDF SIADKIQQIL TSTGFSDKRA RSMDIDDFIR
   301  LLHGFNAEGI HFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIMT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 24 nTPM
  • blood vessel: 20 nTPM
  • smooth muscle: 20 nTPM
  • breast: 18 nTPM
  • pancreas: 18 nTPM
  • adipose tissue: 17 nTPM

Single-cell type

  • cardiomyocytes: 79 nCPM
  • cone photoreceptor cells: 77 nCPM
  • migrating cytotrophoblasts: 73 nCPM
  • decidual stromal cells: 71 nCPM
  • esophageal basal cells: 69 nCPM
  • megakaryocytes: 68 nCPM

Immune cell

  • MAIT T-cell: 13 nTPM
  • plasmacytoid DC: 12 nTPM
  • naive CD4 T-cell: 12 nTPM
  • memory CD4 T-cell: 11 nTPM
  • memory B-cell: 10 nTPM
  • naive CD8 T-cell: 9.7 nTPM

Brain region

  • hypothalamus: 1.7 nTPM
  • cerebellum: 1.3 nTPM
  • midbrain: 1.3 nTPM
  • pons: 1.3 nTPM
  • spinal cord: 1.3 nTPM
  • white matter: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
-1.26
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DIMT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIMT1 as an antibody target. Whether an autoantibody or antibody against DIMT1 could matter depends on whether native DIMT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIMT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DIMT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DIMT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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