Seroatlas · Human Serome Atlas

DAPL1

Death-associated protein-like 1

Also known as: DAPL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0PJW8
Gene: DAPL1
Ensembl: ENSG00000163331
Chromosome: 2
Canonical length: 107 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Microtubules

OverviewNCBI Gene

Predicted to enable ribosome binding activity; translation initiation factor binding activity; and translation repressor activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of CD8-positive, alpha-beta T cell activation; and negative regulation of metabolic process. Predicted to act upstream of or within cell population proliferation and gene expression. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>A0PJW8|DAPL1
     1  MANEVQDLLS PRKGGHPPAV KAGGMRISKK QEIGTLERHT KKTGFEKTSA IANVAKIQTL
    61  DALNDALEKL NYKFPATVHM AHQKPTPALE KVVPLKRIYI IQQPRKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 293 nTPM

Expression across tissuesHPA

Tissue

skin: 293 nTPM
esophagus: 234 nTPM
epididymis: 186 nTPM
retina: 107 nTPM
vagina: 102 nTPM
cervix: 94 nTPM

Single-cell type

esophageal suprabasal cells: 1,285 nCPM
esophageal basal cells: 930 nCPM
ocular epithelial cells: 638 nCPM
müller glia: 579 nCPM
fallopian secretory cells: 412 nCPM
suprabasal keratinocytes: 361 nCPM

Immune cell

plasmacytoid DC: 1.1 nTPM
basophil: 1 nTPM
classical monocyte: 0.7 nTPM
NK-cell: 0.7 nTPM
intermediate monocyte: 0.5 nTPM
eosinophil: 0.4 nTPM

Brain region

cerebral cortex: 20 nTPM
hypothalamus: 19 nTPM
midbrain: 11 nTPM
thalamus: 9.3 nTPM
pons: 5.2 nTPM
basal ganglia: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.58
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DAPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DAPL1 as an antibody target. Whether an autoantibody or antibody against DAPL1 could matter depends on whether native DAPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DAPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DAPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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