Seroatlas · Human Serome Atlas

EIF5A2

Eukaryotic translation initiation factor 5A-2

Also known as: IF5A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZV4
Gene: EIF5A2
Ensembl: ENSG00000163577
Chromosome: 3
Canonical length: 153 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q9GZV4|EIF5A2
     1  MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG
    61  IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS LLTETGEVRE DLKLPEGELG
   121  KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK PCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF5A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

testis: 27 nTPM
stomach: 8.6 nTPM
smooth muscle: 6.7 nTPM
choroid plexus: 4.9 nTPM
blood vessel: 4.8 nTPM
cerebral cortex: 4.8 nTPM

Single-cell type

late spermatids: 1,292 nCPM
early spermatids: 380 nCPM
parietal cells: 242 nCPM
late primary spermatocytes: 187 nCPM
melanocytes: 25 nCPM
nk-cells: 20 nCPM

Immune cell

basophil: 15 nTPM
gdT-cell: 12 nTPM
memory CD8 T-cell: 12 nTPM
T-reg: 11 nTPM
NK-cell: 8.8 nTPM
MAIT T-cell: 8.7 nTPM

Brain region

pons: 23 nTPM
white matter: 20 nTPM
medulla oblongata: 19 nTPM
cerebral cortex: 18 nTPM
cerebellum: 18 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 1.24
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF5A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF5A2 as an antibody target. Whether an autoantibody or antibody against EIF5A2 could matter depends on whether native EIF5A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF5A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF5A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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