EIF5A

Protein identityUniProt · HPA

UniProt accession

P63241

Gene

EIF5A

Ensembl

ENSG00000132507

Chromosome

17

Canonical length

154 aa

Protein class

Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables U6 snRNA binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>P63241|EIF5A
     1  MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG
    61  IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG
   121  KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

596 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF5A.

Disease | AllUniProt

Conditions EIF5A is implicated in, by any mechanism.

• Faundes-Banka syndrome (FABAS) MIM:619376

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 52 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Faundes-Banka syndrome
• Neurodevelopmental disorder

Disease | ImmuneIEDB

Conditions an epitope on EIF5A was assayed in.

• melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0.74

gnomAD missense Z

2.41

DepMap mean gene effect

-0.98

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to virus
• positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
• positive regulation of transcription by RNA polymerase II
• positive regulation of translational elongation
• positive regulation of translational termination
• translational elongation
• tumor necrosis factor-mediated signaling pathway

Molecular functions

• ribosome binding
• RNA binding
• translation elongation factor activity
• U6 snRNA binding

Cellular components

• annulate lamellae
• cytoplasm
• cytosol
• endoplasmic reticulum membrane
• membrane
• nuclear pore
• nucleus
• synapse

Protein domainsUniProt · Pfam · InterPro

• Translation elongation factor IF5A-like
• Translation protein SH3-like domain superfamily
• Nucleic acid-binding, OB-fold
• Large ribosomal subunit protein uL2, domain 2
• Translation initiation factor 5A, hypusine site
• Translation initiation factor 5A, C-terminal
• Translation initiation factor 5A-like, N-terminal
• Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
• Translation initiation factor 5A-like, N-terminal

KeywordsUniProt

• Acetylation
• Cytoplasm
• Elongation factor
• Endoplasmic reticulum
• Hypusine
• Membrane
• Nucleus
• Protein biosynthesis
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of EIF5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DAPL1
• DHPS
• DOHH
• SDCBP