Seroatlas · Human Serome Atlas

FAM32A

Protein FAM32A

Also known as: DKFZP586O0120, FA32A_HUMAN, OTAG-12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y421
Gene: FAM32A
Ensembl: ENSG00000105058
Chromosome: 19
Canonical length: 112 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in apoptotic process. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>Q9Y421|FAM32A
     1  MEAYEQVQKG PLKLKGVAEL GVTKRKKKKK DKDKAKLLEA MGTSKKNEEE KRRGLDKRTP
    61  AQAAFEKMQE KRQMERILKK ASKTHKQRVE DFNRHLDTLT EHYDIPKVSW TK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM32A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

liver: 92 nTPM
bone marrow: 89 nTPM
duodenum: 73 nTPM
blood vessel: 73 nTPM
cerebral cortex: 71 nTPM
small intestine: 71 nTPM

Single-cell type

esophageal apical cells: 258 nCPM
platelets: 162 nCPM
megakaryocytes: 136 nCPM
esophageal suprabasal cells: 134 nCPM
extravillous trophoblasts: 132 nCPM
migrating cytotrophoblasts: 118 nCPM

Immune cell

eosinophil: 549 nTPM
non-classical monocyte: 392 nTPM
total PBMC: 343 nTPM
intermediate monocyte: 339 nTPM
basophil: 278 nTPM
classical monocyte: 267 nTPM

Brain region

cerebral cortex: 60 nTPM
basal ganglia: 55 nTPM
thalamus: 55 nTPM
hippocampal formation: 54 nTPM
amygdala: 52 nTPM
pons: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.03
gnomAD missense Z: 1.43
DepMap mean gene effect: -0.85
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic process

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein FAM32A
FAM32A

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM32A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CWC22

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM32A as an antibody target. Whether an autoantibody or antibody against FAM32A could matter depends on whether native FAM32A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM32A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM32A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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