Seroatlas · Human Serome Atlas

CRYGC

Gamma-crystallin C

Also known as: CRGC_HUMAN, CRYG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07315
Gene
CRYGC
Ensembl
ENSG00000163254
Chromosome
2
Canonical length
174 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>P07315|CRYGC
     1  MGKITFYEDR AFQGRSYETT TDCPNLQPYF SRCNSIRVES GCWMLYERPN YQGQQYLLRR
    61  GEYPDYQQWM GLSDSIRSCC LIPQTVSHRL RLYEREDHKG LMMELSEDCP SIQDRFHLSE
   121  IRSLHVLEGC WVLYELPNYR GRQYLLRPQE YRRCQDWGAM DAKAGSLRRV VDLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRYGC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
1.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.6 nTPM
  • epididymis: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • late primary spermatocytes: 3.6 nCPM
  • undifferentiated spermatogonia: 2 nCPM
  • late spermatids: 1.1 nCPM
  • early spermatids: 0.6 nCPM
  • differentiating spermatogonia: 0.4 nCPM
  • early primary spermatocytes: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.3 nTPM
  • pons: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • hypothalamus: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CRYGC.

Disease | AllUniProt

Conditions CRYGC is implicated in, by any mechanism.

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 111 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cataract 2, multiple types
  • Nuclear pulverulent cataract
  • CRYGC-related disorder
  • Developmental cataract
  • Cataract 2, Coppock-like

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
-0.6
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRYGC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRYGC as an antibody target. Whether an autoantibody or antibody against CRYGC could matter depends on whether native CRYGC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRYGC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRYGC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRYGC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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