A1BG
Alpha-1B-glycoprotein
Also known as: A1BG_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P04217
- Gene
- A1BG
- Ensembl
- ENSG00000121410
- Chromosome
- 19
- Canonical length
- 495 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
495 residues, UniProt reviewed canonical sequence.
>P04217|A1BG
1 MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ AHLETPDFQL
61 FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG WTQLSKLLEL TGPKSLPAPW
121 LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL RREGDHEFLE VPEAQEDVEA TFPVHQPGNY
181 SCSYRTDGEG ALSEPSATVT IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD
241 FQLRRGEKEL LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI
301 LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ SPAGTEALFE
361 LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP PRPQLRATWS GAVLAGRDAV
421 LRCEGPIPDV TFELLREGET KAVKTVRTPG AAANLELIFV GPQHAGNYRC RYRSWVPHTF
481 ESELSDPVEL LVAESLocalizationUniProt · AlphaFold · HPA
Whether an antibody against A1BG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 565 nTPM
Expression across tissuesHPA
Tissue
- liver: 565 nTPM
- fallopian tube: 0.7 nTPM
- cerebral cortex: 0.3 nTPM
- lymph node: 0.3 nTPM
- endometrium: 0.2 nTPM
- heart muscle: 0.2 nTPM
Single-cell type
- oligodendrocytes: 23 nCPM
- ependymal cells: 17 nCPM
- podocytes: 7.7 nCPM
- brain excitatory neurons: 7.3 nCPM
- other brain neurons: 5.5 nCPM
- microglia: 4.9 nCPM
Immune cell
- plasmacytoid DC: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- choroid plexus: 1.1 nTPM
- cerebellum: 0.9 nTPM
- basal ganglia: 0.8 nTPM
- midbrain: 0.8 nTPM
- white matter: 0.8 nTPM
- cerebral cortex: 0.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.21
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.09
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of A1BG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads A1BG as an antibody target. Whether an autoantibody or antibody against A1BG could matter depends on whether native A1BG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
A1BG is annotated as secreted, so native A1BG circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label A1BG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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