Seroatlas · Human Serome Atlas

COA1

Cytochrome c oxidase assembly factor 1 homolog

Also known as: C7orf44, COA1_HUMAN, FLJ10803, MITRAC15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZY4
Gene: COA1
Ensembl: ENSG00000106603
Chromosome: 7
Canonical length: 146 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respiratory chain complex I assembly. Located in cytosol and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>Q9GZY4|COA1
     1  MMWQKYAGSR RSMPLGARIL FHGVFYAGGF AIVYYLIQKF HSRALYYKLA VEQLQSHPEA
    61  QEALGPPLNI HYLKLIDREN FVDIVDAKLK IPVSGSKSEG LLYVHSSRGG PFQRWHLDEV
   121  FLELKDGQQI PVFKLSGENG DEVKKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

tongue: 77 nTPM
skeletal muscle: 76 nTPM
heart muscle: 59 nTPM
choroid plexus: 52 nTPM
tonsil: 37 nTPM
lymph node: 35 nTPM

Single-cell type

myonuclei: 487 nCPM
cardiomyocytes: 327 nCPM
erythrocyte progenitors: 240 nCPM
choroid plexus epithelial cells: 233 nCPM
adipocytes: 203 nCPM
megakaryocyte-erythroid progenitors: 199 nCPM

Immune cell

neutrophil: 36 nTPM
naive B-cell: 35 nTPM
memory B-cell: 33 nTPM
naive CD8 T-cell: 32 nTPM
NK-cell: 32 nTPM
intermediate monocyte: 29 nTPM

Brain region

choroid plexus: 24 nTPM
cerebellum: 23 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 20 nTPM
hypothalamus: 20 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.01
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cytochrome c oxidase assembly factor 1
Cytochrome oxidase complex assembly protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COA1 as an antibody target. Whether an autoantibody or antibody against COA1 could matter depends on whether native COA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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