Seroatlas · Human Serome Atlas

CFAP20

Cilia- and flagella-associated protein 20

Also known as: C16orf80, CFA20_HUMAN, fSAP23, GTL3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6A4
Gene
CFAP20
Ensembl
ENSG00000070761
Chromosome
16
Canonical length
193 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Equatorial segment,Principal piece

OverviewNCBI Gene

Enables RNA binding activity. Involved in several processes, including positive regulation of feeding behavior; protein polyglutamylation; and regulation of cilium beat frequency involved in ciliary motility. Located in microtubule cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q9Y6A4|CFAP20
     1  MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT
    61  CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR RRFRASNYQS TTRVKPFICT
   121  MPMRLDDGWN QIQFNLLDFT RRAYGTNYIE TLRVQIHANC RIRRVYFSDR LYSEDELPAE
   181  FKLYLPVQNK AKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 40 nTPM
  • basal ganglia: 40 nTPM
  • choroid plexus: 39 nTPM
  • thymus: 37 nTPM
  • hypothalamus: 35 nTPM
  • cerebral cortex: 35 nTPM

Single-cell type

  • early spermatids: 403 nCPM
  • late primary spermatocytes: 163 nCPM
  • late spermatids: 162 nCPM
  • cytotrophoblasts: 127 nCPM
  • fallopian tube ciliated cells: 117 nCPM
  • respiratory ciliated cells: 106 nCPM

Immune cell

  • T-reg: 95 nTPM
  • basophil: 89 nTPM
  • NK-cell: 67 nTPM
  • naive CD4 T-cell: 64 nTPM
  • plasmacytoid DC: 57 nTPM
  • memory B-cell: 55 nTPM

Brain region

  • hypothalamus: 35 nTPM
  • spinal cord: 34 nTPM
  • white matter: 34 nTPM
  • cerebral cortex: 33 nTPM
  • basal ganglia: 32 nTPM
  • midbrain: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFAP20.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 25 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
DepMap mean gene effect
-0.53
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP20 as an antibody target. Whether an autoantibody or antibody against CFAP20 could matter depends on whether native CFAP20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFAP20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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