Seroatlas · Human Serome Atlas

CBY3

Sperm annulus positionning complex subunit Chibby3

Also known as: CBY3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NI87
Gene: CBY3
Ensembl: ENSG00000204659
Chromosome: 5
Canonical length: 242 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for CBY3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>A6NI87|CBY3
     1  MWASRDHLPE PDLGDAAPPG SPSSFWTSGL PRQERSTSRQ RSRGSPSSTC VPYKVHALAT
    61  FECSATSHAS RLWQTLQQFW ADHISRPFSP RRPPLRRMPS LSTFYLLDHN TRQAELGLAY
   121  GAPCMRLSNQ AFVFRGGRWT TESQLARTRS PLLSRTAWGW KAQVQRSKSQ VLLEENNYLK
   181  LQQELLIDML TETMARMHLL EKQRNPEVIP TAAARAGQRK MRKRAGASAG VLMIQPCALD
   241  SQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CBY3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
spinal cord: 0.8 nTPM
cerebellum: 0.7 nTPM
midbrain: 0.6 nTPM
hypothalamus: 0.5 nTPM
basal ganglia: 0.4 nTPM

Single-cell type

papillary tip epithelial cells: 3.1 nCPM
renal collecting duct principal cells: 3.1 nCPM
brain inhibitory neurons: 3 nCPM
brain excitatory neurons: 2.8 nCPM
other brain neurons: 2.8 nCPM
bergmann glia: 2.4 nCPM

Immune cell

naive B-cell: 0.9 nTPM
memory CD4 T-cell: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
T-reg: 0.3 nTPM

Brain region

medulla oblongata: 3.5 nTPM
cerebellum: 3.1 nTPM
white matter: 3.1 nTPM
pons: 3 nTPM
thalamus: 3 nTPM
amygdala: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.03
DepMap dependency class: none

OntologyGO

Biological processes

Cellular components

sperm annulus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CBY3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CIBAR1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CBY3 as an antibody target. Whether an autoantibody or antibody against CBY3 could matter depends on whether native CBY3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CBY3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CBY3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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