Complement System Regulators and Virion Entry Mediators
IPR051503
Definition
The protein family is involved in the regulation of the complement system, a critical component of the innate immune response. Members of the family include glycoproteins that inhibit complement activation on self cells by binding to specific markers, accelerating the decay of C3 convertase, and acting as cofactors for factor I to degrade C3b. Some family members also mediate cellular responses by interacting with receptors, aiding in pathogen phagocytosis and destruction. Additionally, certain proteins within the family are associated with lipid metabolism and may influence tissue-bound complement fragments, competing with physiological inhibitors. The family also includes a protein that aids in viral entry into host cells by participating in the dissolution of virion membranes.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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