Seroatlas · Human Serome Atlas

CDK20

Cyclin-dependent kinase 20

Also known as: CCRK, CDK20_HUMAN, p42, PNQALRE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZL9
Gene
CDK20
Ensembl
ENSG00000156345
Chromosome
9
Canonical length
346 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Connecting piece,Mid piece,Principal piece,End piece

OverviewNCBI Gene

The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q8IZL9|CDK20
     1  MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGFPNQALR EIKALQEMED
    61  NQYVVQLKAV FPHGGGFVLA FEFMLSDLAE VVRHAQRPLA QAQVKSYLQM LLKGVAFCHA
   121  NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGSRLY THQVATRWYR APELLYGARQ
   181  YDQGVDLWSV GCIMGELLNG SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI
   241  SFKEQVPMPL EEVLPDVSPQ ALDLLGQFLL YPPHQRIAAS KALLHQYFFT APLPAHPSEL
   301  PIPQRLGGPA PKAHPGPPHI HDFHVDRPLE ESLLNPELIR PFILEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 18 nTPM
  • cerebral cortex: 15 nTPM
  • testis: 15 nTPM
  • adrenal gland: 14 nTPM
  • basal ganglia: 13 nTPM
  • pituitary gland: 13 nTPM

Single-cell type

  • late primary spermatocytes: 46 nCPM
  • fallopian tube ciliated cells: 24 nCPM
  • endometrial ciliated cells: 19 nCPM
  • respiratory ciliated cells: 19 nCPM
  • oocytes: 18 nCPM
  • epididymal efferent duct ciliated cells: 14 nCPM

Immune cell

  • NK-cell: 3.6 nTPM
  • naive CD4 T-cell: 2.3 nTPM
  • naive CD8 T-cell: 1.6 nTPM
  • T-reg: 1.5 nTPM
  • memory CD4 T-cell: 1.4 nTPM
  • memory CD8 T-cell: 1 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • hypothalamus: 17 nTPM
  • cerebral cortex: 15 nTPM
  • basal ganglia: 15 nTPM
  • hippocampal formation: 11 nTPM
  • white matter: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
gnomAD missense Z
-0.94
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK20 as an antibody target. Whether an autoantibody or antibody against CDK20 could matter depends on whether native CDK20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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