Lipid Phosphate Formation and Regulation
IPR050187
Definition
The protein family is involved in the phosphorylation of various lipids, acting as lipid kinases with a range of specificities and functions. Members of the family catalyze the formation of lipid phosphates such as sphingosine-1-phosphate, dihydrosphingosine 1-phosphate, phosphatidic acid, and ceramide 1-phosphate, which play roles in cell signaling, proliferation, apoptosis, stress response, and membrane trafficking. Some family members also possess acetyltransferase activity and are involved in epigenetic regulation and inflammatory responses. The family includes sphingosine kinases, diacylglycerol kinases, ceramide kinases, and other lipid kinases with unidentified substrates. These enzymes are key in lipid metabolism and are implicated in various cellular processes, including the production of lipoteichoic acid, mitochondrial protein import, and the regulation of programmed cell death in plants.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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