Seroatlas · Human Serome Atlas

CEP85L

Centrosomal protein of 85 kDa-like

Also known as: bA57K17.2, C6orf204, CE85L_HUMAN, NY-BR-15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SZL2
Gene: CEP85L
Ensembl: ENSG00000111860
Chromosome: 6
Canonical length: 805 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene was identified as a breast cancer antigen. Nothing more is known of its function at this time. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>Q5SZL2|CEP85L
     1  MWGRFLAPEA SGRDSPGGAR SFPAGPDYSS AWLPANESLW QATTVPSNHR NNHIRRHSIA
    61  SDSGDTGIGT SCSDSVEDHS TSSGTLSFKP SQSLITLPTA HVMPSNSSAS ISKLRESLTP
   121  DGSKWSTSLM QTLGNHSRGE QDSSLDMKDF RPLRKWSSLS KLTAPDNCGQ GGTVCREESR
   181  NGLEKIGKAK ALTSQLRTIG PSCLHDSMEM LRLEDKEINK KRSSTLDCKY KFESCSKEDF
   241  RASSSTLRRQ PVDMTYSALP ESKPIMTSSE AFEPPKYLML GQQAVGGVPI QPSVRTQMWL
   301  TEQLRTNPLE GRNTEDSYSL APWQQQQIED FRQGSETPMQ VLTGSSRQSY SPGYQDFSKW
   361  ESMLKIKEGL LRQKEIVIDR QKQQITHLHE RIRDNELRAQ HAMLGHYVNC EDSYVASLQP
   421  QYENTSLQTP FSEESVSHSQ QGEFEQKLAS TEKEVLQLNE FLKQRLSLFS EEKKKLEEKL
   481  KTRDRYISSL KKKCQKESEQ NKEKQRRIET LEKYLADLPT LDDVQSQSLQ LQILEEKNKN
   541  LQEALIDTEK KLEEIKKQCQ DKETQLICQK KKEKELVTTV QSLQQKVERC LEDGIRLPML
   601  DAKQLQNEND NLRQQNETAS KIIDSQQDEI DRMILEIQSM QGKLSKEKLT TQKMMEELEK
   661  KERNVQRLTK ALLENQRQTD ETCSLLDQGQ EPDQSRQQTV LSKRPLFDLT VIDQLFKEMS
   721  CCLFDLKALC SILNQRAQGK EPNLSLLLGI RSMNCSAEET ENDHSTETLT KKLSDVCQLR
   781  RDIDELRTTI SDRYAQDMGD NCITQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP85L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
thymus: 18 nTPM
lymph node: 13 nTPM
tongue: 11 nTPM
bone marrow: 11 nTPM
tonsil: 9.1 nTPM

Single-cell type

cardiomyocytes: 4,034 nCPM
late spermatids: 1,279 nCPM
myonuclei: 732 nCPM
early spermatids: 620 nCPM
bergmann glia: 619 nCPM
thyrotrophs: 561 nCPM

Immune cell

neutrophil: 16 nTPM
intermediate monocyte: 12 nTPM
non-classical monocyte: 11 nTPM
classical monocyte: 11 nTPM
eosinophil: 9 nTPM
naive CD4 T-cell: 7.1 nTPM

Brain region

cerebellum: 38 nTPM
midbrain: 30 nTPM
thalamus: 28 nTPM
pons: 25 nTPM
hypothalamus: 25 nTPM
white matter: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEP85L.

Disease | AllUniProt

Conditions CEP85L is implicated in, by any mechanism.

Lissencephaly 10 (LIS10) MIM:618873

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 204 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Posterior Predominant Lissencephaly
Lissencephaly 10
Lissencephaly
Neurodevelopmental disorder
Thick corpus callosum

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

neuron migration

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP85L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP85L as an antibody target. Whether an autoantibody or antibody against CEP85L could matter depends on whether native CEP85L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP85L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP85L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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