Seroatlas · Human Serome Atlas

CEP85

Centrosomal protein of 85 kDa

Also known as: CCDC21, CEP85_HUMAN, DKFZP434L0117

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P2H3
Gene: CEP85
Ensembl: ENSG00000130695
Chromosome: 1
Canonical length: 762 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Golgi apparatus,Vesicles,Centrosome,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

762 residues, UniProt reviewed canonical sequence.

>Q6P2H3|CEP85
     1  MAMQEKYPTE GISHVTSPSS DVIQKGSSLG TEWQTPVISE PFRSRFSRCS SVADSGDTAI
    61  GTSCSDIAED FCSSSGSPPF QPIKSHVTIP TAHVMPSTLG TSPAKPNSTP VGPSSSKLPL
   121  SGLAESVGMT RNGDLGAMKH SPGLSRDLMY FSGATGENGI EQSWFPAVGH ERQEEARKFD
   181  IPSMESTLNQ SAMMETLYSD PHHRVRFHNP RTSTSKELYR VLPEAKKAPG SGAVFERNGP
   241  HSNSSGVLPL GLQPAPGLSK PLPSQVWQPS PDTWHPREQS CELSTCRQQL ELIRLQMEQM
   301  QLQNGAICHH PAAFGPSLPI LEPAQWISIL NSNEHLLKEK ELLIDKQRKH ISQLEQKVRE
   361  SELQVHSALL GRPAPFGDVC LLRLQELQRE NTFLRAQFAQ KTEALSREKI DLEKKLSASE
   421  VEVQLIRESL KVALQKHSEE VKKQEERVKG RDKHINNLKK KCQKESEQNR EKQQRIETLE
   481  RYLADLPTLE DHQKQSQQLK DSELKSTELQ EKVTELESLL EETQAICREK EIQLESLRQR
   541  EAEFSSAGHS LQDKQSVEET SGEGPEVEME SWQKRYDSLQ KIVEKQQQKM DQLRSQVQSL
   601  EQEVAQEEGT SQALREEAQR RDSALQQLRT AVKELSVQNQ DLIEKNLTLQ EHLRQAQPGS
   661  PPSPDTAQLA LELHQELASC LQDLQAVCSI VTQRAQGHDP NLSLLLGIHS AQHPETQLDL
   721  QKPDVIKRKL EEVQQLRRDI EDLRTTMSDR YAQDMGENCV TQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP85 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 125 nTPM
tongue: 62 nTPM
testis: 29 nTPM
heart muscle: 22 nTPM
bone marrow: 20 nTPM
retina: 13 nTPM

Single-cell type

myonuclei: 321 nCPM
cardiomyocytes: 148 nCPM
syncytiotrophoblasts: 95 nCPM
early primary spermatocytes: 86 nCPM
renal collecting duct intercalated cells: 82 nCPM
differentiating spermatogonia: 59 nCPM

Immune cell

eosinophil: 19 nTPM
non-classical monocyte: 7.4 nTPM
classical monocyte: 6.5 nTPM
intermediate monocyte: 6.1 nTPM
basophil: 5 nTPM
myeloid DC: 4.9 nTPM

Brain region

white matter: 31 nTPM
pons: 21 nTPM
basal ganglia: 19 nTPM
medulla oblongata: 17 nTPM
thalamus: 17 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.34
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP85 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP85 as an antibody target. Whether an autoantibody or antibody against CEP85 could matter depends on whether native CEP85 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP85 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP85 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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