Seroatlas · Human Serome Atlas

CEACAM16

Cell adhesion molecule CEACAM16

Also known as: CEA16_HUMAN, DFNA4B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2WEN9
Gene: CEACAM16
Ensembl: ENSG00000213892
Chromosome: 19
Canonical length: 425 aa
Protein class: Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location: Secreted in other tissues
Quaternary structure: Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q2WEN9|CEACAM16
     1  MALTGYSWLL LSATFLNVGA EISITLEPAQ PSEGDNVTLV VHGLSGELLA YSWYAGPTLS
    61  VSYLVASYIV STGDETPGPA HTGREAVRPD GSLDIQGILP RHSGTYILQT FNRQLQTEVG
   121  YGHVQVHEIL AQPTVLANST ALVERRDTLR LMCSSPSPTA EVRWFFNGGA LPVALRLGLS
   181  PDGRVLARHG IRREEAGAYQ CEVWNPVSVS RSEPINLTVY FGPERVAILQ DSTTRTGCTI
   241  KVDFNTSLTL WCVSRSCPEP EYVWTFNGQA LKNGQDHLNI SSMTAAQEGT YTCIAKNTKT
   301  LLSGSASVVV KLSAAAVATM IVPVPTKPTE GQDVTLTVQG YPKDLLVYAW YRGPASEPNR
   361  LLSQLPSGTW IAGPAHTGRE VGFPNCSLLV QKLNLTDTGR YTLKTVTVQG KTETLEVELQ
   421  VAPLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEACAM16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 1.9 nTPM

Expression across tissuesHPA

Tissue

pancreas: 1.9 nTPM
tonsil: 0.5 nTPM
adrenal gland: 0.2 nTPM
retina: 0.2 nTPM
skeletal muscle: 0.2 nTPM
pituitary gland: 0.1 nTPM

Single-cell type

retinal bipolar cells: 7.7 nCPM
esophageal apical cells: 5 nCPM
paneth cells: 3.9 nCPM
thyrotrophs: 3.6 nCPM
colonocytes: 3.3 nCPM
goblet cells: 2.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.4 nTPM
thalamus: 0.3 nTPM
cerebral cortex: 0.2 nTPM
medulla oblongata: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEACAM16.

Disease | AllUniProt

Conditions CEACAM16 is implicated in, by any mechanism.

Deafness, autosomal dominant, 4B (DFNA4B) MIM:614614
Deafness, autosomal recessive, 113 (DFNB113) MIM:618410

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 313 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autosomal dominant nonsyndromic hearing loss 4B
Hearing loss, autosomal recessive 113
Rare genetic deafness
Nonsyndromic genetic hearing loss
Ear malformation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sensory perception of sound

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEACAM16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEACAM16 as an antibody target. Whether an autoantibody or antibody against CEACAM16 could matter depends on whether native CEACAM16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEACAM16 is annotated as secreted, so native CEACAM16 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CEACAM16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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