TECTB
Beta-tectorin
Also known as: TECTB_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96PL2
- Gene
- TECTB
- Ensembl
- ENSG00000119913
- Chromosome
- 10
- Canonical length
- 329 aa
- Protein class
- Predicted membrane proteins, Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a non-collagenous glycoprotein component of the tectorial membrane, which covers the auditory hair cells in the cochlea of the inner ear. A similar protein in mouse functions in low-frequency hearing. [provided by RefSeq, Jul 2013]
Canonical amino-acid sequenceUniProt
329 residues, UniProt reviewed canonical sequence.
>Q96PL2|TECTB
1 MVTKAFVLLA IFAEASAKSC APNKADVILV FCYPKTIITK IPECPYGWEV HQLALGGLCY
61 NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH IVSNDTTVIV KNQPVNYSFS
121 CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT FESQLSLNFY TNAKFSIKKE APFVLEASEI
181 GSDLFAGVEA KGLSIRFKVV LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGRDH
241 RATFQFNAFR FQNIPKLSKV WLHCETFICD SEKLSCPVTC DKRKRLLRDQ TGGVLVVELS
301 LRSRGFSSLY SFSDVLHHLI MMLGICAVLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TECTB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 0.5 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 0.5 nTPM
- liver: 0.4 nTPM
- basal ganglia: 0.2 nTPM
- midbrain: 0.2 nTPM
- thyroid gland: 0.2 nTPM
- amygdala: 0.1 nTPM
Single-cell type
- retinal pigment epithelial cells: 17 nCPM
- salivary acinar cells: 4 nCPM
- late spermatids: 3.6 nCPM
- epididymal principal cells: 2.6 nCPM
- cone photoreceptor cells: 2.1 nCPM
- mucous neck cells: 2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.3 nTPM
- pons: 0.3 nTPM
- basal ganglia: 0.2 nTPM
- midbrain: 0.2 nTPM
- spinal cord: 0.2 nTPM
- thalamus: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.12
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TECTB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TECTB as an antibody target. Whether an autoantibody or antibody against TECTB could matter depends on whether native TECTB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TECTB is annotated at the cell surface, where native TECTB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TECTB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...