Seroatlas · Human Serome Atlas

CDK17

Cyclin-dependent kinase 17

Also known as: CDK17_HUMAN, PCTAIRE2, PCTK2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00537
Gene: CDK17
Ensembl: ENSG00000059758
Chromosome: 12
Canonical length: 523 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q00537|CDK17
     1  MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEENSSKDNE PIVKNGRPPT SHSMHSFLHQ
    61  YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN LKMGSDGESD QASGTSSDEV
   121  QSPTGVCLRN RIHRRISMED LNKRLSLPAD IRIPDGYLEK LQINSPPFDQ PMSRRSRRAS
   181  LSEIGFGKME TYIKLEKLGE GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS
   241  LLKDLKHANI VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG
   301  LAYCHRRKVL HRDLKPQNLL INEKGELKLA DFGLARAKSV PTKTYSNEVV TLWYRPPDVL
   361  LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL IFRLLGTPSQ ETWPGISSNE
   421  EFKNYNFPKY KPQPLINHAP RLDSEGIELI TKFLQYESKK RVSAEEAMKH VYFRSLGPRI
   481  HALPESVSIF SLKEIQLQKD PGFRNSSYPE TGHGKNRRQS MLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 45 nTPM
cerebral cortex: 41 nTPM
basal ganglia: 38 nTPM
placenta: 30 nTPM
smooth muscle: 28 nTPM
hippocampal formation: 26 nTPM

Single-cell type

nk-cells: 523 nCPM
neutrophils: 394 nCPM
mast cells: 391 nCPM
vascular endothelial cells: 384 nCPM
t-cells: 382 nCPM
neutrophil progenitors: 380 nCPM

Immune cell

basophil: 67 nTPM
NK-cell: 32 nTPM
memory CD8 T-cell: 25 nTPM
naive CD4 T-cell: 25 nTPM
MAIT T-cell: 24 nTPM
neutrophil: 23 nTPM

Brain region

white matter: 133 nTPM
basal ganglia: 121 nTPM
hippocampal formation: 102 nTPM
cerebral cortex: 97 nTPM
hypothalamus: 85 nTPM
spinal cord: 83 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDK17.

Disease | ImmuneIEDB

Conditions an epitope on CDK17 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 2.64
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK17 as an antibody target. Whether an autoantibody or antibody against CDK17 could matter depends on whether native CDK17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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