Seroatlas · Human Serome Atlas

SECTM1

Secreted and transmembrane protein 1

Also known as: K12, SCTM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVN6
Gene: SECTM1
Ensembl: ENSG00000141574
Chromosome: 17
Canonical length: 248 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q8WVN6|SECTM1
     1  MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN TVMSCNISNA
    61  FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA QLVIKGARDS HAGLYMWHLV
   121  GHQRNNRQVT LEVSGAEPQS APDTGFWPVP AVVTAVFILL VALVMFAWYR CRCSQQRREK
   181  KFFLLEPQMK VAALRAGAQQ GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP
   241  LFPYAADP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SECTM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

small intestine: 85 nTPM
duodenum: 63 nTPM
spleen: 45 nTPM
appendix: 38 nTPM
salivary gland: 37 nTPM
colon: 34 nTPM

Single-cell type

neutrophils: 134 nCPM
monocytes: 81 nCPM
enterocytes: 74 nCPM
foveolar cells: 52 nCPM
kupffer cells: 38 nCPM
colonocytes: 36 nCPM

Immune cell

neutrophil: 155 nTPM
intermediate monocyte: 58 nTPM
non-classical monocyte: 57 nTPM
classical monocyte: 31 nTPM
myeloid DC: 8.4 nTPM
total PBMC: 4.5 nTPM

Brain region

medulla oblongata: 6.1 nTPM
cerebral cortex: 4.3 nTPM
pons: 4.1 nTPM
choroid plexus: 3.8 nTPM
thalamus: 3.3 nTPM
hypothalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0.06
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin-like fold
Secreted and transmembrane protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SECTM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SECTM1 as an antibody target. Whether an autoantibody or antibody against SECTM1 could matter depends on whether native SECTM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SECTM1 is annotated at the cell surface, where native SECTM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SECTM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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