Seroatlas · Human Serome Atlas

TSKU

Tsukushi

Also known as: E2IG4, LRRC54, TSK, TSK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUA8
Gene
TSKU
Ensembl
ENSG00000182704
Chromosome
11
Canonical length
353 aa
Protein class
Predicted secreted proteins
Subcellular location
Nucleoplasm,Nuclear bodies
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including cholesterol efflux; cholesterol homeostasis; and nervous system development. Predicted to act upstream of or within several processes, including ciliary body morphogenesis; negative regulation of Wnt signaling pathway; and telencephalon development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q8WUA8|TSKU
     1  MPWPLLLLLA VSGAQTTRPC FPGCQCEVET FGLFDSFSLT RVDCSGLGPH IMPVPIPLDT
    61  AHLDLSSNRL EMVNESVLAG PGYTTLAGLD LSHNLLTSIS PTAFSRLRYL ESLDLSHNGL
   121  TALPAESFTS SPLSDVNLSH NQLREVSVSA FTTHSQGRAL HVDLSHNLIH RLVPHPTRAG
   181  LPAPTIQSLN LAWNRLHAVP NLRDLPLRYL SLDGNPLAVI GPGAFAGLGG LTHLSLASLQ
   241  RLPELAPSGF RELPGLQVLD LSGNPKLNWA GAEVFSGLSS LQELDLSGTN LVPLPEALLL
   301  HLPALQSVSV GQDVRCRRLV REGTYPRRPG SSPKVALHCV DTRDSAARGP TIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSKU can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
222 nTPM

Expression across tissuesHPA

Tissue

  • liver: 222 nTPM
  • cervix: 124 nTPM
  • vagina: 97 nTPM
  • adipose tissue: 95 nTPM
  • breast: 82 nTPM
  • esophagus: 63 nTPM

Single-cell type

  • hepatocytes: 674 nCPM
  • decidual stromal cells: 137 nCPM
  • retinal pigment epithelial cells: 132 nCPM
  • extravillous trophoblasts: 96 nCPM
  • esophageal apical cells: 80 nCPM
  • adipocytes: 63 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • choroid plexus: 70 nTPM
  • hippocampal formation: 25 nTPM
  • cerebellum: 24 nTPM
  • cerebral cortex: 23 nTPM
  • pons: 21 nTPM
  • amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.85
gnomAD missense Z
0.6
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSKU in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSKU as an antibody target. Whether an autoantibody or antibody against TSKU could matter depends on whether native TSKU is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSKU is annotated as secreted, so native TSKU circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TSKU as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSKU. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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