Seroatlas · Human Serome Atlas

TEX9

Testis-expressed protein 9

Also known as: TEX9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6V9
Gene: TEX9
Ensembl: ENSG00000151575
Chromosome: 15
Canonical length: 391 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Vesicles,Primary cilium,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q8N6V9|TEX9
     1  MAGRSLCLTR SSVPGTPFPP PVQQPSTPGP DLLALEEEYK RLNAELQAKT ADVVQQAKEI
    61  IRDRQEVRSR PVSTQMKSCD DEDDYSLRGL LPSEGIVHLH SETKPKTKNI DPVNKVQNKL
   121  HSANKGRKTN SSVKLKYSDV QTADDVAIPE DFSDFSLAKT ISKIEGQLEE EGLPEYIDDI
   181  FSGVSNDIGT EAQIRFLKAK LHVMQEELDN VVCECNKKED EIQNLKSQVK NFEEDFMRQQ
   241  RTINMQQSQV EKYKTLFEEA NKKYDGLQQQ LSSVERELEN KRRLQKQAAS SQSATEVRLN
   301  RALEEAEKYK LELSKLRQNN KDIANEEHKK IEVLKSENKK LEKQKGELMI GFKKQLKLID
   361  VLKRQKMHIE AAKMLSFTEE EFMKALEWGN S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 11 nTPM
testis: 9.4 nTPM
pituitary gland: 8.8 nTPM
thyroid gland: 7.5 nTPM
salivary gland: 6.8 nTPM
choroid plexus: 6.6 nTPM

Single-cell type

ependymal cells: 465 nCPM
respiratory ciliated cells: 345 nCPM
fallopian tube ciliated cells: 288 nCPM
choroid plexus epithelial cells: 256 nCPM
endometrial ciliated cells: 219 nCPM
epididymal efferent duct ciliated cells: 198 nCPM

Immune cell

memory B-cell: 10 nTPM
naive B-cell: 8.5 nTPM
basophil: 2.1 nTPM
total PBMC: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

choroid plexus: 14 nTPM
medulla oblongata: 7.9 nTPM
midbrain: 6.7 nTPM
spinal cord: 5.7 nTPM
white matter: 5.2 nTPM
hypothalamus: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: -0.75
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

centriolar satellite

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX9 as an antibody target. Whether an autoantibody or antibody against TEX9 could matter depends on whether native TEX9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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