Seroatlas · Human Serome Atlas

CAMKK1

Calcium/calmodulin-dependent protein kinase kinase 1

Also known as: CAMKKA, DKFZp761M0423, KKCC1_HUMAN, MGC34095

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N5S9
Gene
CAMKK1
Ensembl
ENSG00000004660
Chromosome
17
Canonical length
505 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q8N5S9|CAMKK1
     1  MEGGPAVCCQ DPRAELVERV AAIDVTHLEE ADGGPEPTRN GVDPPPRARA ASVIPGSTSR
    61  LLPARPSLSA RKLSLQERPA GSYLEAQAGP YATGPASHIS PRAWRRPTIE SHHVAISDAE
   121  DCVQLNQYKL QSEIGKGAYG VVRLAYNESE DRHYAMKVLS KKKLLKQYGF PRRPPPRGSQ
   181  AAQGGPAKQL LPLERVYQEI AILKKLDHVN VVKLIEVLDD PAEDNLYLVF DLLRKGPVME
   241  VPCDKPFSEE QARLYLRDVI LGLEYLHCQK IVHRDIKPSN LLLGDDGHVK IADFGVSNQF
   301  EGNDAQLSST AGTPAFMAPE AISDSGQSFS GKALDVWATG VTLYCFVYGK CPFIDDFILA
   361  LHRKIKNEPV VFPEEPEISE ELKDLILKML DKNPETRIGV PDIKLHPWVT KNGEEPLPSE
   421  EEHCSVVEVT EEEVKNSVRL IPSWTTVILV KSMLRKRSFG NPFEPQARRE ERSMSAPGNL
   481  LVKEGFGEGG KSPELPGVQE DEAAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMKK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 70 nTPM
  • cerebellum: 48 nTPM
  • basal ganglia: 41 nTPM
  • hippocampal formation: 30 nTPM
  • amygdala: 29 nTPM
  • salivary gland: 28 nTPM

Single-cell type

  • somatotrophs: 99 nCPM
  • sertoli cells: 91 nCPM
  • retinal bipolar cells: 81 nCPM
  • retinal ganglion cells: 73 nCPM
  • brain excitatory neurons: 65 nCPM
  • lactotrophs: 63 nCPM

Immune cell

  • neutrophil: 2.7 nTPM
  • non-classical monocyte: 2.1 nTPM
  • intermediate monocyte: 2 nTPM
  • eosinophil: 1.9 nTPM
  • classical monocyte: 0.9 nTPM
  • myeloid DC: 0.8 nTPM

Brain region

  • cerebral cortex: 137 nTPM
  • white matter: 89 nTPM
  • hippocampal formation: 70 nTPM
  • basal ganglia: 68 nTPM
  • amygdala: 68 nTPM
  • pons: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
1.34
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAMKK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAMKK1 as an antibody target. Whether an autoantibody or antibody against CAMKK1 could matter depends on whether native CAMKK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAMKK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAMKK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAMKK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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