Seroatlas · Human Serome Atlas

CAMK4

Calcium/calmodulin-dependent protein kinase type IV

Also known as: CaMK-GR, CaMKIV, KCC4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16566
Gene: CAMK4
Ensembl: ENSG00000152495
Chromosome: 5
Canonical length: 473 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Endoplasmic reticulum

OverviewNCBI Gene

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q16566|CAMK4
     1  MLKVTVPSCS ASSCSSVTAS AAPGTASLVP DYWIDGSNRD ALSDFFEVES ELGRGATSIV
    61  YRCKQKGTQK PYALKVLKKT VDKKIVRTEI GVLLRLSHPN IIKLKEIFET PTEISLVLEL
   121  VTGGELFDRI VEKGYYSERD AADAVKQILE AVAYLHENGI VHRDLKPENL LYATPAPDAP
   181  LKIADFGLSK IVEHQVLMKT VCGTPGYCAP EILRGCAYGP EVDMWSVGII TYILLCGFEP
   241  FYDERGDQFM FRRILNCEYY FISPWWDEVS LNAKDLVRKL IVLDPKKRLT TFQALQHPWV
   301  TGKAANFVHM DTAQKKLQEF NARRKLKAAV KAVVASSRLG SASSSHGSIQ ESHKASRDPS
   361  PIQDGNEDMK AIPEGEKIQG DGAQAAVKGA QAELMKVQAL EKVKGADINA EEAPKMVPKA
   421  VEDGIKVADL ELEEGLAEEK LKTVEEAAAP REGQGSSAVG FEVPQQDVIL PEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 53 nTPM
thymus: 52 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 9.6 nTPM
testis: 8.8 nTPM
lymph node: 7.6 nTPM

Single-cell type

t-cells: 687 nCPM
brain excitatory neurons: 600 nCPM
brain inhibitory neurons: 524 nCPM
retinal bipolar cells: 309 nCPM
early spermatids: 304 nCPM
bergmann glia: 275 nCPM

Immune cell

naive CD4 T-cell: 33 nTPM
MAIT T-cell: 24 nTPM
T-reg: 21 nTPM
naive CD8 T-cell: 19 nTPM
memory CD4 T-cell: 17 nTPM
memory CD8 T-cell: 13 nTPM

Brain region

cerebellum: 174 nTPM
basal ganglia: 88 nTPM
cerebral cortex: 41 nTPM
hippocampal formation: 37 nTPM
amygdala: 32 nTPM
white matter: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAMK4.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 98 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability
Involuntary movements

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.51
gnomAD missense Z: 1.81
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAMK4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CAMKK1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAMK4 as an antibody target. Whether an autoantibody or antibody against CAMK4 could matter depends on whether native CAMK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAMK4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAMK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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