Seroatlas · Human Serome Atlas

CACNG8

Voltage-dependent calcium channel gamma-8 subunit

Also known as: CCG8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WXS5
Gene
CACNG8
Ensembl
ENSG00000142408
Chromosome
19
Canonical length
425 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q8WXS5|CACNG8
     1  MESLKRWNEE RGLWCEKGVQ VLLTTVGAFA AFGLMTIAIS TDYWLYTRAL ICNTTNLTAG
    61  GDDGTPHRGG GGASEKKDPG GLTHSGLWRI CCLEGLKRGV CVKINHFPED TDYDHDSAEY
   121  LLRVVRASSI FPILSAILLL LGGVCVAASR VYKSKRNIIL GAGILFVAAG LSNIIGVIVY
   181  ISANAGEPGP KRDEEKKNHY SYGWSFYFGG LSFILAEVIG VLAVNIYIER SREAHCQSRS
   241  DLLKAGGGAG GSGGSGPSAI LRLPSYRFRY RRRSRSSSRS SEPSPSRDAS PGGPGGPGFA
   301  STDISMYTLS RDPSKGSVAA GLAGAGGGGG GAVGAFGGAA GGAGGGGGGG GGAGAERDRG
   361  GASGFLTLHN AFPKEAGGGV TVTVTGPPAP PAPAPPAPSA PAPGTLAKEA AASNTNTLNR
   421  KTTPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACNG8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 34 nTPM
  • cerebral cortex: 23 nTPM
  • amygdala: 16 nTPM
  • basal ganglia: 14 nTPM
  • hypothalamus: 8.7 nTPM
  • midbrain: 3.4 nTPM

Single-cell type

  • brain inhibitory neurons: 86 nCPM
  • retinal horizontal cells: 80 nCPM
  • brain excitatory neurons: 76 nCPM
  • other brain neurons: 54 nCPM
  • bergmann glia: 44 nCPM
  • oligodendrocyte progenitor cells: 43 nCPM

Immune cell

  • basophil: 5.4 nTPM
  • eosinophil: 0.6 nTPM
  • neutrophil: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 85 nTPM
  • hippocampal formation: 83 nTPM
  • amygdala: 34 nTPM
  • white matter: 33 nTPM
  • basal ganglia: 33 nTPM
  • hypothalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.96
gnomAD missense Z
2.34
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACNG8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACNG8 as an antibody target. Whether an autoantibody or antibody against CACNG8 could matter depends on whether native CACNG8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACNG8 is annotated at the cell surface, where native CACNG8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CACNG8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CACNG8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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