CNIH2
Protein cornichon homolog 2
Also known as: CNIH-2, CNIH2_HUMAN, Cnil, MGC50896
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6PI25
- Gene
- CNIH2
- Ensembl
- ENSG00000174871
- Chromosome
- 11
- Canonical length
- 160 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Canonical amino-acid sequenceUniProt
160 residues, UniProt reviewed canonical sequence.
>Q6PI25|CNIH2
1 MAFTFAAFCY MLTLVLCASL IFFVIWHIIA FDELRTDFKN PIDQGNPARA RERLKNIERI
61 CCLLRKLVVP EYSIHGLFCL MFLCAAEWVT LGLNIPLLFY HLWRYFHRPA DGSEVMYDAV
121 SIMNADILNY CQKESWCKLA FYLLSFFYYL YSMVYTLVSFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CNIH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 424 nTPM
Expression across tissuesHPA
Tissue
- hippocampal formation: 424 nTPM
- amygdala: 170 nTPM
- cerebral cortex: 151 nTPM
- basal ganglia: 146 nTPM
- hypothalamus: 86 nTPM
- pituitary gland: 43 nTPM
Single-cell type
- pancreatic islet cells: 108 nCPM
- early spermatids: 82 nCPM
- other brain neurons: 52 nCPM
- late primary spermatocytes: 51 nCPM
- brain excitatory neurons: 37 nCPM
- late spermatids: 34 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 545 nTPM
- hippocampal formation: 481 nTPM
- amygdala: 169 nTPM
- basal ganglia: 140 nTPM
- hypothalamus: 113 nTPM
- thalamus: 97 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.31
- gnomAD pLI
- 0.95
- gnomAD missense Z
- 2.25
- DepMap mean gene effect
- -0.19
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CNIH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CNIH2 as an antibody target. Whether an autoantibody or antibody against CNIH2 could matter depends on whether native CNIH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CNIH2 is annotated at the cell surface, where native CNIH2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CNIH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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