Seroatlas · Human Serome Atlas

C1QTNF8

Complement C1q tumor necrosis factor-related protein 8

Also known as: C1QT8_HUMAN, CTRP8, UNQ5829

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60827
Gene: C1QTNF8
Ensembl: ENSG00000184471
Chromosome: 16
Canonical length: 252 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted - unknown location
Quaternary structure: Homotrimer

OverviewNCBI Gene

Involved in positive regulation of cell motility. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>P60827|C1QTNF8
     1  MAAPALLLLA LLLPVGAWPG LPRRPCVHCC RPAWPPGPYA RVSDRDLWRG DLWRGLPRVR
    61  PTIDIEILKG EKGEAGVRGR AGRSGKEGPP GARGLQGRRG QKGQVGPPGA ACRRAYAAFS
   121  VGRREGLHSS DHFQAVPFDT ELVNLDGAFD LAAGRFLCTV PGVYFLSLNV HTWNYKETYL
   181  HIMLNRRPAA VLYAQPSERS VMQAQSLMLL LAAGDAVWVR MFQRDRDNAI YGEHGDLYIT
   241  FSGHLVKPAA EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QTNF8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 2.4 nTPM
fallopian tube: 1.7 nTPM
pituitary gland: 1.6 nTPM
hypothalamus: 0.7 nTPM
basal ganglia: 0.6 nTPM
hippocampal formation: 0.4 nTPM

Single-cell type

endometrial ciliated cells: 18 nCPM
ependymal cells: 14 nCPM
epididymal efferent duct ciliated cells: 11 nCPM
fallopian tube ciliated cells: 5 nCPM
cardiomyocytes: 4.7 nCPM
leydig cells: 3.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 4.3 nTPM
spinal cord: 3.3 nTPM
medulla oblongata: 3 nTPM
pons: 1.5 nTPM
white matter: 1.5 nTPM
hypothalamus: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.97
gnomAD pLI: 0
gnomAD missense Z: -0.79
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of cell motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C1QTNF8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RXFP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QTNF8 as an antibody target. Whether an autoantibody or antibody against C1QTNF8 could matter depends on whether native C1QTNF8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QTNF8 is annotated as secreted, so native C1QTNF8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QTNF8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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