Seroatlas · Human Serome Atlas

BRD9

Bromodomain-containing protein 9

Also known as: BRD9_HUMAN, FLJ13441, SMARCI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H8M2
Gene
BRD9
Ensembl
ENSG00000028310
Chromosome
5
Canonical length
597 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of SWI/SNF complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>Q9H8M2|BRD9
     1  MGKKHKKHKA EWRSSYEDYA DKPLEKPLKL VLKVGGSEVT ELSGSGHDSS YYDDRSDHER
    61  ERHKEKKKKK KKKSEKEKHL DDEERRKRKE EKKRKREREH CDTEGEADDF DPGKKVEVEP
   121  PPDRPVRACR TQPAENESTP IQQLLEHFLR QLQRKDPHGF FAFPVTDAIA PGYSMIIKHP
   181  MDFGTMKDKI VANEYKSVTE FKADFKLMCD NAMTYNRPDT VYYKLAKKIL HAGFKMMSKQ
   241  AALLGNEDTA VEEPVPEVVP VQVETAKKSK KPSREVISCM FEPEGNACSL TDSTAEEHVL
   301  ALVEHAADEA RDRINRFLPG GKMGYLKRNG DGSLLYSVVN TAEPDADEEE THPVDLSSLS
   361  SKLLPGFTTL GFKDERRNKV TFLSSATTAL SMQNNSVFGD LKSDEMELLY SAYGDETGVQ
   421  CALSLQEFVK DAGSYSKKVV DDLLDQITGG DHSRTLFQLK QRRNVPMKPP DEAKVGDTLG
   481  DSSSSVLEFM SMKSYPDVSV DISMLSSLGK VKKELDPDDS HLNLDETTKL LQDLHEAQAE
   541  RGGSRPSSNL SSLSNASERD QHHLGSPSRL SVGEQPDVTH DPYEFLQSPE PAASAKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 17 nTPM
  • cerebral cortex: 14 nTPM
  • basal ganglia: 14 nTPM
  • midbrain: 13 nTPM
  • amygdala: 13 nTPM
  • choroid plexus: 13 nTPM

Single-cell type

  • early spermatids: 197 nCPM
  • corticotrophs: 124 nCPM
  • late spermatids: 105 nCPM
  • somatotrophs: 86 nCPM
  • endometrial stromal cells: 79 nCPM
  • thyrotrophs: 77 nCPM

Immune cell

  • basophil: 7.1 nTPM
  • naive B-cell: 6.1 nTPM
  • T-reg: 5.2 nTPM
  • memory B-cell: 4.9 nTPM
  • memory CD8 T-cell: 4.5 nTPM
  • memory CD4 T-cell: 4.2 nTPM

Brain region

  • medulla oblongata: 20 nTPM
  • thalamus: 20 nTPM
  • cerebral cortex: 19 nTPM
  • white matter: 18 nTPM
  • amygdala: 18 nTPM
  • basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.02
gnomAD missense Z
1.26
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRD9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRD9 as an antibody target. Whether an autoantibody or antibody against BRD9 could matter depends on whether native BRD9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRD9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRD9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BRD9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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