Seroatlas · Human Serome Atlas

BMP3

Bone morphogenetic protein 3

Also known as: BMP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P12645
Gene: BMP3
Ensembl: ENSG00000152785
Chromosome: 4
Canonical length: 472 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>P12645|BMP3
     1  MAGASRLLFL WLGCFCVSLA QGERPKPPFP ELRKAVPGDR TAGGGPDSEL QPQDKVSEHM
    61  LRLYDRYSTV QAARTPGSLE GGSQPWRPRL LREGNTVRSF RAAAAETLER KGLYIFNLTS
   121  LTKSENILSA TLYFCIGELG NISLSCPVSG GCSHHAQRKH IQIDLSAWTL KFSRNQSQLL
   181  GHLSVDMAKS HRDIMSWLSK DITQLLRKAK ENEEFLIGFN ITSKGRQLPK RRLPFPEPYI
   241  LVYANDAAIS EPESVVSSLQ GHRNFPTGTV PKWDSHIRAA LSIERRKKRS TGVLLPLQNN
   301  ELPGAEYQYK KDEVWEERKP YKTLQAQAPE KSKNKKKQRK GPHRKSQTLQ FDEQTLKKAR
   361  RKQWIEPRNC ARRYLKVDFA DIGWSEWIIS PKSFDAYYCS GACQFPMPKS LKPSNHATIQ
   421  SIVRAVGVVP GIPEPCCVPE KMSSLSILFF DENKNVVLKV YPNMTVESCA CR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 8.9 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 8.9 nTPM
colon: 8.3 nTPM
small intestine: 6.8 nTPM
rectum: 6.3 nTPM
lung: 5.1 nTPM
ovary: 5.1 nTPM

Single-cell type

colonocytes: 55 nCPM
papillary tip epithelial cells: 43 nCPM
urothelial cells: 41 nCPM
ependymal cells: 40 nCPM
salivary duct cells: 38 nCPM
enterocytes: 28 nCPM

Immune cell

naive B-cell: 0.7 nTPM
NK-cell: 0.3 nTPM
basophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

thalamus: 3.6 nTPM
midbrain: 2.4 nTPM
medulla oblongata: 2.3 nTPM
spinal cord: 2.2 nTPM
hypothalamus: 2 nTPM
pons: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.06
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BMP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACVR2B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMP3 as an antibody target. Whether an autoantibody or antibody against BMP3 could matter depends on whether native BMP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMP3 is annotated as secreted, so native BMP3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BMP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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