NTF3

Protein identityUniProt · HPA

UniProt accession

P20783

Gene

NTF3

Ensembl

ENSG00000185652

Chromosome

12

Canonical length

257 aa

Protein class

Cancer-related genes, Predicted secreted proteins, RAS pathway related proteins

Subcellular location

Vesicles

Secretome location

Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>P20783|NTF3
     1  MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
    61  STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM
   121  EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK
   181  TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI
   241  RIDTSCVCAL SRKIGRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

27 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.93

gnomAD missense Z

1.74

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor protein tyrosine kinase signaling pathway
• cell-cell signaling
• induction of positive chemotaxis
• modulation of chemical synaptic transmission
• negative regulation of neuron apoptotic process
• nerve development
• nerve growth factor signaling pathway
• nervous system development
• neuron projection morphogenesis
• positive regulation of cell migration
• positive regulation of cell population proliferation
• positive regulation of MAPK cascade
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of receptor internalization
• regulation of apoptotic process
• signal transduction

Molecular functions

• chemoattractant activity
• growth factor activity
• nerve growth factor receptor binding
• signaling receptor binding

Cellular components

• axon
• dendrite
• extracellular region
• extracellular space
• synaptic vesicle

Protein domainsUniProt · Pfam · InterPro

• Nerve growth factor-related
• Nerve growth factor conserved site
• Nerve growth factor-like
• Cystine-knot cytokine
• Nerve growth factor family
• Neurotrophin-3
• Neutrophin-3, N-terminal
• Neutrophin-3 N-terminus

KeywordsUniProt

• Cleavage on pair of basic residues
• Disulfide bond
• Glycoprotein
• Growth factor
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of NTF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BDNF