B3GNT2

Protein identityUniProt · HPA

UniProt accession

Q9NY97

Gene

B3GNT2

Ensembl

ENSG00000170340

Chromosome

2

Canonical length

397 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins

Subcellular location

Vesicles

OverviewNCBI Gene

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>Q9NY97|B3GNT2
     1  MSVGRRRIKL LGILMMANVF IYFIMEVSKS SSQEKNGKGE VIIPKEKFWK ISTPPEAYWN
    61  REQEKLNRQY NPILSMLTNQ TGEAGRLSNI SHLNYCEPDL RVTSVVTGFN NLPDRFKDFL
   121  LYLRCRNYSL LIDQPDKCAK KPFLLLAIKS LTPHFARRQA IRESWGQESN AGNQTVVRVF
   181  LLGQTPPEDN HPDLSDMLKF ESEKHQDILM WNYRDTFFNL SLKEVLFLRW VSTSCPDTEF
   241  VFKGDDDVFV NTHHILNYLN SLSKTKAKDL FIGDVIHNAG PHRDKKLKYY IPEVVYSGLY
   301  PPYAGGGGFL YSGHLALRLY HITDQVHLYP IDDVYTGMCL QKLGLVPEKH KGFRTFDIEE
   361  KNKNNICSYV DLMLVHSRKP QEMIDIWSQL QSAHLKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GNT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

69 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.41

gnomAD pLI

0.89

gnomAD missense Z

1.28

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon guidance
• cellular response to leukemia inhibitory factor
• keratan sulfate proteoglycan biosynthetic process
• poly-N-acetyllactosamine biosynthetic process
• protein O-linked glycosylation
• sensory perception of smell

Molecular functions

• 3-N-acetylglucosaminyltransferase activity
• N-acetyllactosaminide beta-1

Cellular components

• Golgi membrane

Protein domainsUniProt · Pfam · InterPro

• Glycosyl transferase, family 31
• Galactosyltransferase

KeywordsUniProt

• Glycoprotein
• Glycosyltransferase
• Golgi apparatus
• Manganese
• Membrane
• Signal-anchor
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of B3GNT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• B3GNT8
• CANX