Seroatlas · Human Serome Atlas

B3GNT8

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

Also known as: B3GALT7, B3GN8_HUMAN, beta3Gn-T8, BGALT15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7M8
Gene
B3GNT8
Ensembl
ENSG00000177191
Chromosome
19
Canonical length
397 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Enables protein N-acetylglucosaminyltransferase activity. Involved in poly-N-acetyllactosamine biosynthetic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>Q7Z7M8|B3GNT8
     1  MRCPKCLLCL SALLTLLGLK VYIEWTSESR LSKAYPSPRG TPPSPTPANP EPTLPANLST
    61  RLGQTIPLPF AYWNQQQWRL GSLPSGDSTE TGGCQAWGAA AATEIPDFAS YPKDLRRFLL
   121  SAACRSFPQW LPGGGGSQVS SCSDTDVPYL LLAVKSEPGR FAERQAVRET WGSPAPGIRL
   181  LFLLGSPVGE AGPDLDSLVA WESRRYSDLL LWDFLDVPFN QTLKDLLLLA WLGRHCPTVS
   241  FVLRAQDDAF VHTPALLAHL RALPPASARS LYLGEVFTQA MPLRKPGGPF YVPESFFEGG
   301  YPAYASGGGY VIAGRLAPWL LRAAARVAPF PFEDVYTGLC IRALGLVPQA HPGFLTAWPA
   361  DRTADHCAFR NLLLVRPLGP QASIRLWKQL QDPRLQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against B3GNT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 19 nTPM
  • small intestine: 18 nTPM
  • esophagus: 12 nTPM
  • colon: 11 nTPM
  • lung: 7 nTPM
  • bone marrow: 4.5 nTPM

Single-cell type

  • esophageal apical cells: 659 nCPM
  • esophageal suprabasal cells: 102 nCPM
  • neutrophils: 74 nCPM
  • enterocytes: 66 nCPM
  • colonocytes: 53 nCPM
  • alveolar cells type 2: 48 nCPM

Immune cell

  • neutrophil: 198 nTPM
  • eosinophil: 147 nTPM
  • basophil: 118 nTPM
  • MAIT T-cell: 35 nTPM
  • non-classical monocyte: 33 nTPM
  • classical monocyte: 20 nTPM

Brain region

  • cerebellum: 4.1 nTPM
  • pons: 3 nTPM
  • white matter: 3 nTPM
  • medulla oblongata: 2.7 nTPM
  • basal ganglia: 2.5 nTPM
  • cerebral cortex: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0
gnomAD missense Z
0.22
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of B3GNT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads B3GNT8 as an antibody target. Whether an autoantibody or antibody against B3GNT8 could matter depends on whether native B3GNT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

B3GNT8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label B3GNT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/B3GNT8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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