TM4SF19
Transmembrane 4 L6 family member 19
Also known as: T4S19_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96DZ7
- Gene
- TM4SF19
- Ensembl
- ENSG00000145107
- Chromosome
- 3
- Canonical length
- 209 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Canonical amino-acid sequenceUniProt
209 residues, UniProt reviewed canonical sequence.
>Q96DZ7|TM4SF19
1 MVSSPCTQAS SRTCSRILGL SLGTAALFAA GANVALLLPN WDVTYLLRGL LGRHAMLGTG
61 LWGGGLMVLT AAILISLMGW RYGCFSKSGL CRSVLTALLS GGLALLGALI CFVTSGVALK
121 DGPFCMFDVS SFNQTQAWKY GYPFKDLHSR NYLYDRSLWN SVCLEPSAAV VWHVSLFSAL
181 LCISLLQLLL VVVHVINSLL GLFCSLCEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TM4SF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 5.8 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 5.8 nTPM
- testis: 4.3 nTPM
- lung: 3.4 nTPM
- esophagus: 3.3 nTPM
- breast: 2.5 nTPM
- skin: 1.7 nTPM
Single-cell type
- esophageal apical cells: 0.1 nCPM
- esophageal suprabasal cells: 0.1 nCPM
- macrophages: 0.1 nCPM
- myonuclei: 0.1 nCPM
- ocular epithelial cells: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- gdT-cell: 15 nTPM
- naive CD8 T-cell: 4.9 nTPM
- memory CD8 T-cell: 3.9 nTPM
- total PBMC: 1.6 nTPM
- memory CD4 T-cell: 1.3 nTPM
- basophil: 0.7 nTPM
Brain region
- thalamus: 8.4 nTPM
- white matter: 4 nTPM
- pons: 3.2 nTPM
- cerebral cortex: 3.1 nTPM
- cerebellum: 2.9 nTPM
- midbrain: 2.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.54
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.7
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TM4SF19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TM4SF19 as an antibody target. Whether an autoantibody or antibody against TM4SF19 could matter depends on whether native TM4SF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TM4SF19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TM4SF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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