Seroatlas · Human Serome Atlas

ANO7

Anoctamin-7

Also known as: ANO7_HUMAN, IPCA-5, NGEP, PCANAP5, PCANAP5L, TMEM16G

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IWH7
Gene: ANO7
Ensembl: ENSG00000146205
Chromosome: 2
Canonical length: 933 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

933 residues, UniProt reviewed canonical sequence.

>Q6IWH7|ANO7
     1  MRMAATAWAG LQGPPLPTLC PAVRTGLYCR DQAHAERWAM TSETSSGSHC ARSRMLRRRA
    61  QEEDSTVLID VSPPEAEKRG SYGSTAHASE PGGQQAAACR AGSPAKPRIA DFVLVWEEDL
   121  KLDRQQDSAA RDRTDMHRTW RETFLDNLRA AGLCVDQQDV QDGNTTVHYA LLSASWAVLC
   181  YYAEDLRLKL PLQELPNQAS NWSAGLLAWL GIPNVLLEVV PDVPPEYYSC RFRVNKLPRF
   241  LGSDNQDTFF TSTKRHQILF EILAKTPYGH EKKNLLGIHQ LLAEGVLSAA FPLHDGPFKT
   301  PPEGPQAPRL NQRQVLFQHW ARWGKWNKYQ PLDHVRRYFG EKVALYFAWL GFYTGWLLPA
   361  AVVGTLVFLV GCFLVFSDIP TQELCGSKDS FEMCPLCLDC PFWLLSSACA LAQAGRLFDH
   421  GGTVFFSLFM ALWAVLLLEY WKRKSATLAY RWDCSDYEDT EERPRPQFAA SAPMTAPNPI
   481  TGEDEPYFPE RSRARRMLAG SVVIVVMVAV VVMCLVSIIL YRAIMAIVVS RSGNTLLAAW
   541  ASRIASLTGS VVNLVFILIL SKIYVSLAHV LTRWEMHRTQ TKFEDAFTLK VFIFQFVNFY
   601  SSPVYIAFFK GRFVGYPGNY HTLFGVRNEE CAAGGCLIEL AQELLVIMVG KQVINNMQEV
   661  LIPKLKGWWQ KFRLRSKKRK AGASAGASQG PWEDDYELVP CEGLFDEYLE MVLQFGFVTI
   721  FVAACPLAPL FALLNNWVEI RLDARKFVCE YRRPVAERAQ DIGIWFHILA GLTHLAVISN
   781  AFLLAFSSDF LPRAYYRWTR AHDLRGFLNF TLARAPSSFA AAHNRTCRYR AFRDDDGHYS
   841  QTYWNLLAIR LAFVIVFEHV VFSVGRLLDL LVPDIPESVE IKVKREYYLA KQALAENEVL
   901  FGTNGTKDEQ PEGSELSSHW TPFTVPKASQ LQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANO7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

prostate: 67 nTPM
stomach: 27 nTPM
colon: 18 nTPM
small intestine: 16 nTPM
duodenum: 10 nTPM
rectum: 10 nTPM

Single-cell type

prostatic glandular cells: 145 nCPM
goblet cells: 125 nCPM
foveolar cells: 85 nCPM
tuft cells: 69 nCPM
oocytes: 32 nCPM
epididymal principal cells: 28 nCPM

Immune cell

NK-cell: 0.4 nTPM
basophil: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

white matter: 6.2 nTPM
medulla oblongata: 5.8 nTPM
cerebral cortex: 5.4 nTPM
thalamus: 4.9 nTPM
pons: 4 nTPM
spinal cord: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chloride transmembrane transport
monoatomic ion transmembrane transport
calcium activated phospholipid scrambling

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANO7 as an antibody target. Whether an autoantibody or antibody against ANO7 could matter depends on whether native ANO7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANO7 is annotated at the cell surface, where native ANO7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANO7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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