Seroatlas · Human Serome Atlas

FKBPL

FK506-binding protein-like

Also known as: DIR1, FKBPL_HUMAN, NG7, WISp39

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UIM3
Gene
FKBPL
Ensembl
ENSG00000204315
Chromosome
6
Canonical length
349 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitotic spindle

OverviewNCBI Gene

The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q9UIM3|FKBPL
     1  METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL
    61  EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL
   121  GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH
   181  SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL
   241  LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG
   301  NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 10 nTPM
  • skin: 9.6 nTPM
  • salivary gland: 6 nTPM
  • testis: 6 nTPM
  • stomach: 5.8 nTPM
  • epididymis: 5.7 nTPM

Single-cell type

  • platelets: 2.8 nCPM
  • bergmann glia: 1.3 nCPM
  • ependymal cells: 1.2 nCPM
  • other brain neurons: 1.2 nCPM
  • renal collecting duct principal cells: 1.2 nCPM
  • brain excitatory neurons: 1 nCPM

Immune cell

  • basophil: 6.7 nTPM
  • NK-cell: 3.5 nTPM
  • neutrophil: 2.6 nTPM
  • intermediate monocyte: 2.5 nTPM
  • memory B-cell: 2.1 nTPM
  • classical monocyte: 1.8 nTPM

Brain region

  • white matter: 4.2 nTPM
  • basal ganglia: 2.6 nTPM
  • medulla oblongata: 2.6 nTPM
  • cerebral cortex: 2.1 nTPM
  • hippocampal formation: 2 nTPM
  • pons: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0
gnomAD missense Z
1.42
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FKBPL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBPL as an antibody target. Whether an autoantibody or antibody against FKBPL could matter depends on whether native FKBPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBPL is annotated as secreted, so native FKBPL circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FKBPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FKBPL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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