Seroatlas · Human Serome Atlas

CASP14

Caspase-14

Also known as: CASPE_HUMAN, MGC119078, MGC119079, MICE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31944
Gene
CASP14
Ensembl
ENSG00000105141
Chromosome
19
Canonical length
242 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>P31944|CASP14
     1  MSNPRSLEEE KYDMSGARLA LILCVTKARE GSEEDLDALE HMFRQLRFES TMKRDPTAEQ
    61  FQEELEKFQQ AIDSREDPVS CAFVVLMAHG REGFLKGEDG EMVKLENLFE ALNNKNCQAL
   121  RAKPKVYIIQ ACRGEQRDPG ETVGGDEIVM VIKDSPQTIP TYTDALHVYS TVEGYIAYRH
   181  DQKGSCFIQT LVDVFTKRKG HILELLTEVT RRMAEAELVQ EGKARKTNPE IQSTLRKRLY
   241  LQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CASP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
459 nTPM

Expression across tissuesHPA

Tissue

  • skin: 459 nTPM
  • cervix: 36 nTPM
  • vagina: 17 nTPM
  • breast: 7.3 nTPM
  • seminal vesicle: 4 nTPM
  • salivary gland: 1.8 nTPM

Single-cell type

  • suprabasal keratinocytes: 65 nCPM
  • ocular epithelial cells: 24 nCPM
  • basal keratinocytes: 11 nCPM
  • late spermatids: 6.2 nCPM
  • extravillous trophoblasts: 5.6 nCPM
  • early spermatids: 2.7 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 3.7 nTPM
  • cerebellum: 2.7 nTPM
  • basal ganglia: 2.6 nTPM
  • cerebral cortex: 2.6 nTPM
  • medulla oblongata: 2.6 nTPM
  • thalamus: 2.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CASP14.

Disease | AllUniProt

Conditions CASP14 is implicated in, by any mechanism.

  • Ichthyosis, congenital, autosomal recessive 12 (ARCI12) MIM:617320

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
-0.18
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CASP14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CASP14 as an antibody target. Whether an autoantibody or antibody against CASP14 could matter depends on whether native CASP14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CASP14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo.

Canonical record: https://seroatlas.com/gene/CASP14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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