Seroatlas · Human Serome Atlas

CFAP69

Cilia- and flagella-associated protein 69

Also known as: C7orf63, CFA69_HUMAN, FAP69, FLJ21062

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5D8W1
Gene: CFAP69
Ensembl: ENSG00000105792
Chromosome: 7
Canonical length: 941 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Acts upstream of or within sperm axoneme assembly. Located in cytoplasm and sperm midpiece. Implicated in spermatogenic failure 24. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

941 residues, UniProt reviewed canonical sequence.

>A5D8W1|CFAP69
     1  MWTEEAGATA EAQESGIRNK SSSSSQIPVV GVVTEDDEAQ DVFKPMDLNR VIKLLEETDK
    61  DGLEEKQLKF VKKLVQCYQN GLPLRDLAQI FKILNLCSGK IKNQPRFIES AYDIIKLCGL
   121  PFLKKKVSDE ITYAEDTANS IALLGDLMKI PSSELRIQIC KCIVDFYHAE PPKKHIPGYQ
   181  QASSSYKIQM AEVGGLAKTM VQSMTLLENQ LVEKLWVLKV LQHLSTSEVN CTIMMKAQAA
   241  SGICTHLNDP DPSGQLLFRS SEILWNLLEK SSKEEVIQQL SNLECLLALK EVFKNLFMRG
   301  FSHYDRQLRN DILVITTIIA QNPEAPMIEC GFTKDLILFA TFNEVKSQNL LVKGLKLSNS
   361  YEDFELKKLL FNVIVILCKD LPTVQLLIDG KVILALFTYV KKPEKQKIID WSAAQHEELQ
   421  LHAIATLSSV APLLIEEYMS CQGNARVLAF LEWCESEDPF FSHGNSFHGT GGRGNKFAQM
   481  RYSLRLLRAV VYLEDETVNK DLCEKGTIQQ MIGIFKNIIS KPNEKEEAIV LEIQSDILLI
   541  LSGLCENHIQ RKEIFGTEGV DIVLHVMKTD PRKLQSGLGY NVLLFSTLDS IWCCILGCYP
   601  SEDYFLEKEG IFLLLDLLAL NQKKFCNLIL GIMVEFCDNP KTAAHVNAWQ GKKDQTAASL
   661  LIKLWRKEEK ELGVKRDKNG KIIDTKKPLF TSFQEEQKII PLPANCPSIA VMDVSENIRA
   721  KIYAILGKLD FENLPGLSAE DFVTLCIIHR YLDFKIGEIW NEIYEEIKLE KLRPVTTDKK
   781  ALEAITTASE NIGKMVASLQ SDIIESQACQ DMQNEQKVYA KIQATHKQRE LANKSWEDFL
   841  ARTSNAKTLK KAKSLQEKAI EASRYHKRPQ NAIFHQTHIK GLNTTVPSGG VVTVESTPAR
   901  LVGGPLVDTD IALKKLPIRG GALQRVKAVK IVDAPKKSIP T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP69 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 51 nTPM
prostate: 24 nTPM
fallopian tube: 13 nTPM
epididymis: 12 nTPM
pituitary gland: 12 nTPM
retina: 12 nTPM

Single-cell type

prostatic glandular cells: 538 nCPM
ependymal cells: 507 nCPM
respiratory ciliated cells: 395 nCPM
endometrial ciliated cells: 370 nCPM
fallopian tube ciliated cells: 338 nCPM
epididymal efferent duct ciliated cells: 288 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 42 nTPM
medulla oblongata: 12 nTPM
midbrain: 12 nTPM
spinal cord: 9 nTPM
white matter: 6.5 nTPM
hypothalamus: 6.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFAP69.

Disease | AllUniProt

Conditions CFAP69 is implicated in, by any mechanism.

Spermatogenic failure 24 (SPGF24) MIM:617959

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 174 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 24
Susceptibility to severe COVID-19
Non-syndromic male infertility due to sperm motility disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
Cilia- and flagella-associated protein 69
Cilia- and flagella-associated protein 69, ARM repeats domain
Cilia- and flagella-associated protein 69, ARM repeat

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP69 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ADGB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP69 as an antibody target. Whether an autoantibody or antibody against CFAP69 could matter depends on whether native CFAP69 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP69 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP69 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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